+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of fructus psoraleae extract on the intestinal absorption kinetics of geniposide and geniposidic acid in rat

Effects of fructus psoraleae extract on the intestinal absorption kinetics of geniposide and geniposidic acid in rat

Molecules 19(6): 7557-7567

Cortex Eucommia has been used as a kidney-tonifying herbal medicine with a long history of compatibility with Fructus Psoraleae. Geniposide (GP) and geniposidic acid (GPA) are the two main chemical components in Cortex Eucommia. In the present study, the effects of Fructus Psoraleae extract (FPE) on intestinal absorption kinetics of GP and GPA in rat were investigated. Twenty four male Sprague-Dawley rats were randomly assigned into four groups which were treated with GP, GPA, GP mixed with FPE and GPA mixed with FPE, respectively, by in situ intestinal perfusion for 3 h. The samples of intestinal perfusion solutions were collected every 30 min, and analyzed by ultra high performance liquid chromatography (UPLC). The curves of time and residual quantities of GP and GPA (lnx) in the intestinal perfusion solution and the cumulative absorption rate were obtained. The results showed that FPE exhibited different effects on the intestinal absorption of GP and GPA in rat: it increased the intestinal absorption of GP (p<0.05), while demonstrated no significant effect on the absorption of GPA.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 052867954

Download citation: RISBibTeXText

PMID: 24914900

DOI: 10.3390/molecules19067557

Related references

Studies on O/W partition coefficient and absorption kinetics of geniposide in fructus gardeniae extract in rat intestine. Zhongguo Zhong Yao Za Zhi 34(14): 1840-1844, 2009

General survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae. Journal of Food and Drug Analysis 26(2): 807-814, 2018

Effects of Gardeniae Fructus extract and geniposide on promoting ligament cell proliferation and collagen synthesis. PhytoTherapy Research 24 Suppl 1: S1-S5, 2010

Inhibitive effects of Fructus Psoraleae extract on dopamine transporter and noradrenaline transporter. Journal of Ethnopharmacology 112(3): 498-506, 2007

Systemic effect of Fructus Psoraleae extract on bone in mice. PhytoTherapy Research 24(10): 1578-1580, 2011

Comparisons of geniposidic acid and geniposide on antitumor and radioprotection after sublethal irradiation. Cancer Letters. 113(1-2): 31-37, 1997

Multiorgan toxicity induced by EtOH extract of Fructus Psoraleae in Wistar rats. Phytomedicine 58: 152874, 2019

Evaluation of hepatotoxicity and cholestasis in rats treated with EtOH extract of Fructus Psoraleae. Journal of Ethnopharmacology 144(1): 73-81, 2013

The effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action. PhytoTherapy Research 27(4): 484-492, 2013

Identification and determination of geniposide, genipin, gardenoside, and geniposidic acid from herbs by HPLC/photodiode-array detection. Journal of Liquid Chromatography 17(10): 2199-2205, 1994

Intestinal absorption properties of flavones and extract of fructus aurantii immaturus in rats. Zhongguo Zhong Yao Za Zhi 35(14): 1850-1854, 2010

Determination of geniposide, gardenoside, geniposidic acid and genipin-1- beta -gentiobioside in Gardenia jasminoides by high-performance liquid chromatography. Journal of Chromatography 455: 410-414, 1988

Comparative investigation on the pharmacokinetics of geniposide in type 2 diabetic and normal rats after oral administration of Fructus Gradeniae extract. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 1033-1034: 180-186, 2017

Suppression of mast cell activity contributes to the osteoprotective effect of an herbal formula containing Herba Epimedii, Fructus Ligustri Lucidi and Fructus Psoraleae. Journal of Pharmacy and Pharmacology 66(3): 437-444, 2014

The effects of notoginsenoside R₁ on the intestinal absorption of geniposide by the everted rat gut sac model. Journal of Ethnopharmacology 142(1): 136-143, 2012