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Effects of krill oil intake on plasma cholesterol and glucose levels in rats fed a high-cholesterol diet

Li, D.-M.; Zhou, D.-Y.; Zhu, B.-W.; Chi, Y.-L.; Sun, L.-M.; Dong, X.-P.; Qin, L.; Qiao, W.-Z.; Murata, Y.

Journal of the Science of Food and Agriculture 93(11): 2669-2675

2013


ISSN/ISBN: 1097-0010
PMID: 23505070
DOI: 10.1002/jsfa.6072
Accession: 052873065

In this study, whole krill oil (WKO) and phospholipid-type krill oil (PKO) with different lipid composition were prepared. The effects of KO intake on plasma cholesterol and glucose levels in Wistar rats fed a high-cholesterol diet (HCD) were investigated. WKO contained 37.63% triglycerides, 48.37% phospholipids, 13.54% free fatty acids and 0.66% cholesterol, whereas the corresponding values for PKO were 0.59, 69.80, 28.53 and 1.09% respectively. Meanwhile, PKO contained much more polyunsaturated fatty acids (PUFA, 37.76%) than WKO (28.36%). After 4 weeks of HCD consumption, plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and glucose increased significantly, but that of high-density lipoprotein cholesterol (HDL-C) decreased significantly. The intake of PKO and WKO for 4 weeks caused a significant reduction in body weight gain and plasma levels of TC and LDL-C in HCD-fed rats. Compared with WKO, PKO was more effective in decreasing plasma TC and LDL-C levels. PKO showed better overall cholesterol-lowering effects than WKO, which may be due to its higher n-3 PUFA levels.

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