+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of long term nasal continuous positive airway pressure on the blood pressure of patients with obstructive sleep apnea hypopnea syndrome



Effects of long term nasal continuous positive airway pressure on the blood pressure of patients with obstructive sleep apnea hypopnea syndrome



Zhonghua Jie he He Hu Xi Za Zhi 35(9): 687-690



To analyze the effects of long term nasal continuous positive airway pressure on the blood pressure of patients with OSAHS. From April 1997 to October 2008, 2898 patients from the First Affiliated Hospital of Fujian Medical University who complained snore during sleeping were studied. Nine hundred eighty cases were diagnosed as OSAHS with hypertension, and these patients were randomly divided into 2 groups: one group was treated with antihypertensive drugs and nasal continuous positive airway pressure (nCPAP), while the other group only received antihypertensive drugs. The polysomnography (PSG) was recorded during sleeping and the blood pressure was remeasured after 6 months or more. All patients were followed up for 5 years to observe the long-term effects of nCPAP or drugs. Systolic and diastolic blood pressure in the nCPAP group significantly decreased after 6 months [(125 ± 16) mm Hg (1 mm Hg = 0.133 kPa) vs (136 ± 19) mm Hg, (83 ± 10) mm Hg vs (95 ± 15) mm Hg, P < 0.05], and the decreasing extent of blood pressure in nCPAP group was more notable than antihypertensive drug group [decreasing extent of systolic blood pressure:(10 ± 11) mm Hg vs (4 ± 11) mm Hg; decreasing extent of diastolic blood pressure: (11 ± 7) mm Hg vs (6 ± 7) mm Hg; P < 0.05]. The total effective rate in nCPAP group was significantly higher than that in antihypertensive drug group (90% vs 38%, P < 0.01). One hundred and eighty three cases in nCPAP group and 157 cases in antihypertensive drug group completed the 5-year follow-up and the blood pressure was controlled within the normal range. Some patients could gradually reduce or stop the use of antihypertensive drugs and the blood pressure didn't appear to rebound. The number of antihypertensive drugs in the nCPAP group was significantly fewer as compared to the antihypertensive drugs group after 2, 3, 4 and 5 years' follow-up. nCPAP is a safe and effective treatment for high blood pressure in patients with OSAHS.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 052874084

Download citation: RISBibTeXText

PMID: 23158073


Related references

Effect of long-term continuous positive airway pressure ventilation on blood pressure in patients with obstructive sleep apnea hypopnea syndrome: a meta-analysis of clinical trials. Zhonghua Yi Xue Za Zhi 87(17): 1177-1180, 2007

Short-term and long-term influences of nasal continuous positive airway pressure to sleep architecture of obstructive sleep apnea hypopnea syndrome. Zhonghua Nei Ke Za Zhi 43(9): 651-653, 2004

Long-term effects of nasal continuous positive airway pressure on pulmonary function and blood gas data in patients with obstructive sleep apnea syndrome. Nihon Kokyuki Gakkai Zasshi 36(12): 1011-1016, 1998

Effects of nasal continuous positive airway pressure short-term treatment on C-reactive protein and intercellular adhesion molecule-1 in patients with obstructive sleep apnea-hypopnea syndrome. Zhong Nan Da Xue Xue Bao. Yi Xue Ban 30(6): 666-669, 2005

Adverse effects and adherence to nasal continuous positive airway pressure in patients with obstructive sleep apnea hypopnea syndrome. Nihon Kokyuki Gakkai Zasshi 42(2): 127-131, 2004

Comparison of manual versus automatic titration in pressure determination for long-term therapy of continuous positive airway pressure in patients with obstructive sleep apnea hypopnea syndrome. Zhonghua Yi Xue Za Zhi 93(36): 2898-2900, 2013

Long-term effects of nasal continuous positive airway pressure on ventilatory patterns of patients with obstructive sleep apnea syndrome. Archivos de Bronconeumologia 33(4): 172-178, 1997

Effects of long-term nasal continuous positive airway pressure on C-reactive protein in patients with obstructive sleep apnea syndrome. Internal Medicine 44(8): 899-900, 2005

The immediate and long term effects of nasal continuous positive airway pressure in the obstructive sleep apnea syndrome. Australian & New Zealand Journal of Medicine 14(4 Suppl. 2): 525, 1984

Effects of long-term nasal continuous positive airway pressure therapy on morphology, function, and mucociliary clearance of nasal epithelium in patients with obstructive sleep apnea syndrome. Laryngoscope 114(8): 1431-1434, 2004

Evaluation of short-term use of nocturnal nasal continuous positive airway pressure for a clinical profile and exercise capacity in adult patients with obstructive sleep apnea-hypopnea syndrome. Lung India 32(3): 225-232, 2015

Effects of short-term continuous positive airway pressure treatment on arterial stiffness in patients with obstructive sleep apnea hypopnea syndrome. Zhonghua Yi Xue Za Zhi 88(17): 1189-1191, 2008

Effects of continuous positive airway pressure on apnea-hypopnea index in obstructive sleep apnea based on long-term compliance. Sleep and Breathing 16(2): 467-471, 2012

Impact of nasal continuous positive airway pressure on heart rhythm in patients with obstructive sleep apnea/hypopnea syndrome. Minerva Medica 105(3): 255-260, 2014

Long-term effects of nasal continuous positive airway pressure on vasodilatory endothelial function in obstructive sleep apnea syndrome. Sleep and Breathing 9(3): 97, 2005