EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Effects of maternal separation on the neurobehavioral development of newborn Wistar rats


Effects of maternal separation on the neurobehavioral development of newborn Wistar rats



Brain Research Bulletin 79(3-4): 208-214



ISSN/ISBN: 0361-9230

PMID: 19150489

DOI: 10.1016/j.brainresbull.2008.12.011

Animal models of neonatal stress, like maternal separation, may provide important correlation with human stress-related disorders. Early maternal deprivation has been shown to cause several short- and long-term neurochemical and behavioral deficits. Little is known about the early neurobehavioral development after postnatal stress. The aim of the present study was to investigate the development of reflexes and motor coordination in male and female pups subjected to maternal deprivation. Pups were removed from their mothers from postnatal day 1-14, for 3h daily. Somatic development (weight gain, eye opening, ear unfolding, incisor eruption) and reflex development was tested during the first 3 weeks. The appearance of the following reflexes was investigated: crossed extensor, grasping, placing, gait, righting and sensory reflexes, and negative geotaxis. Timely performance of negative geotaxis, righting and gait were also tested daily during the first 3 weeks. Motor coordination and open-field tests were performed on postnatal weeks 3-5 (rotarod, elevated grid-walk, footfault, rope suspension, inclined board and walk initiation tests). The results revealed that a 3-h-long daily maternal separation did not lead to a marked delay or enhancement in reflex development and motor coordination. A subtle enhancement was observed in the appearance of hindlimb grasp and gait reflexes, and a better performance in footfault test in male rats suffering from maternal deprivation. In contrast, female maternally deprived (MD) rats displayed a slight delay in forelimb grasp and air righting reflex appearance, and surface righting performance. Open-field activity was not changed in maternally deprived rats. In summary, our present observations indicate that maternal deprivation does not induce drastic changes in early neurodevelopment, therefore, further research is needed to determine the onset of behavioral alterations in subject with maternal deprivation history. Gender differences described in this study could help to understand how gender-specific differences in early life experience-induced stress-related disorders appear in adult life.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052875173

Download citation: RISBibTeXText

Related references

Effects of lipopolysaccharide administration and maternal deprivation on anxiety and depressive symptoms in male and female Wistar rats: Neurobehavioral and biochemical assessments. Behavioural Brain Research 362: 46-55, 2019

Anesthésie maternelle durant l'accouchement: effets maternels et fœtaux, devenir cognitif du nouveau-né - Maternal anesthesia for delivery: maternal and fetal effects, neurobehavioral development of the newborn. Revue de Medecine Perinatale 5(4): 222-229, 2013

Comparison of maternal separation and early handling in terms of their neurobehavioral effects in aged rats. Neurobiology of Aging 23(3): 457-466, 2002

Effects of maternal food restriction on physical growth and neurobehavior in newborn Wistar rats. Brain Research Bulletin 83(1-2): 1-8, 2010

Effects of perinatal asphyxia on the neurobehavioral and retinal development of newborn rats. Brain Research 1255: 42-50, 2009

Effects of maternal separation on brain nociceptin/orphanin FQ peptide levels in male Wistar rats. Pharmacology Biochemistry and Behavior 73(1): 123-129, 2002

Effects of maternal separation on voluntary ethanol intake and brain peptide systems in female Wistar rats. Pharmacology Biochemistry and Behavior 81(3): 506-516, 2005

Long-term effects of maternal separation on ethanol intake and brain opioid and dopamine receptors in male Wistar rats. Neuroscience 121(3): 787-799, 2003

Early maternal separation: neurobehavioral consequences in mother rats. Behavioural Brain Research 248: 25-31, 2013

Maternal exposure to diphenhydramine during the fetal period in rats: effects on physical and neurobehavioral development and on neurochemical parameters. Neurotoxicology and Teratology 26(5): 681-692, 2004

Exposure of pregnant rats to stress and/or sertraline: Side effects on maternal health and neurobehavioral development of male offspring. Life Sciences 285: 119960, 2021

Effects of maternal separation on baseline sleep and cold stress-induced sleep rebound in adult Wistar rats. Sleep 27(6): 1146-1153, 2004

Effects of maternal caffeine consumption on ovarian follicle development in wistar rats offspring. Journal of Reproduction and Infertility 12(1): 15-22, 2011

Effects of maternal oral morphine consumption on neural tube development in Wistar rats. Brain Research. Developmental Brain Research 159(1): 12-17, 2005

The effects of PACAP and PACAP antagonist on the neurobehavioral development of newborn rats. Behavioural Brain Research 140(1-2): 131-139, 2003