+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of rapid distraction rate on new bone formation during mandibular distraction osteogenesis in goats



Effects of rapid distraction rate on new bone formation during mandibular distraction osteogenesis in goats



Injury 40(8): 831-834



Distraction osteogenesis typically requires a long treatment period, which can lead to bone and soft-tissue infection and considerable patient discomfort. Use of a rapid distraction rate in craniofacial distraction osteogenesis to shorten the distraction period is possible owing to the unique characteristics of craniofacial bones, including an abundant blood supply and rapid bone healing compared with long bones. The effects of using a rapid distraction rate in the treatment of craniofacial deformities are currently unclear, however. The objective of this study was to investigate the effects of a rapid distraction rate on new bone formation during mandibular distraction osteogenesis in goats. Sixteen goats were randomly divided into four groups consisting of four goats each. In Groups A, B, and C, the right mandible of each goat was distracted at a rate of 0.8mm/d, 1.6mm/d, and 2.0mm/d, respectively; Group D was the control group and did not undergo distraction. Six weeks after the conclusion of distraction, bone densitometry and three-point bending testing were performed in all groups. The mean bone density value of goats in Group A was significantly higher than those of all the other groups (p<0.05), and the mean bone density value of goats in Group C was significantly lower than those of all the other groups (p<0.05). The mean curve slope, peak stress, bending modulus, and energy to failure values of Groups A, B, and C were all significantly lower than those of the control group (p<0.05). As the distraction rate increased, the curve slope and peak stress values gradually declined (p<0.05). Use of a rapid distraction rate in mandibular distraction osteogenesis may have detrimental effects on the quality of new bone, despite the abundant blood supply of craniofacial bones.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052882853

Download citation: RISBibTeXText

PMID: 19217101

DOI: 10.1016/j.injury.2008.09.011


Related references

Effects of Local Low-Dose Alendronate Injections Into the Distraction Gap on New Bone Formation and Distraction Rate on Distraction Osteogenesis. Journal of Craniofacial Surgery 28(8): 2174-2178, 2017

Effects of bone morphogenetic protein 2 gene therapy on new bone formation during mandibular distraction osteogenesis at rapid rate in rabbits. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics 112(1): 50-57, 2011

Cellular effect of low-level laser therapy on the rate and quality of bone formation in mandibular distraction osteogenesis. Photomedicine and Laser Surgery 32(6): 315-321, 2014

Effect of distraction rates on expression of bone morphogenetic proteins in rabbit mandibular distraction osteogenesis. Journal of Cranio-Maxillo-Facial Surgery 34(5): 263-269, 2006

Innovation in anterior mandibular alveolar distraction osteogenesis: introduction of a new bone-borne distraction device and first clinical results. Journal of Cranio-Maxillo-Facial Surgery 40(8): E503-E508, 2012

Experimental evaluation of the effects of zoledronic acid on regenerate bone formation and osteoporosis in mandibular distraction osteogenesis. Journal of Oral and Maxillofacial Surgery 64(8): 1232-1236, 2006

Bending of the distraction site during mandibular distraction osteogenesis in the rabbit: a model for studying segment control and side effects. Journal of Oral and Maxillofacial Surgery 59(7): 779-788, 2001

The effects of distraction frequencies on the expression of the proliferating cell nuclear antigen in the osteoblasts of the gap tissue during mandibular distraction osteogenesis. 2007

Why high frequency of distraction improved the bone formation in distraction osteogenesis?. Medical Hypotheses 74(5): 871-873, 2010

Preliminary investigation into the effects of electrical stimulation on mandibular distraction osteogenesis in goats. International Journal of Oral and Maxillofacial Surgery 33(1): 42-47, 2004

Mandibular distraction using bone morphogenic protein and rapid distraction in neonates with Pierre Robin syndrome. Journal of Craniofacial Surgery 21(4): 1158-1161, 2010

Mode of new bone formation following distraction osteogenesis in mandibular lengthening. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 16(2): 83-85, 2002

Mandibular Midline Distraction Osteogenesis with a Bone-borne, Tooth-borne or Hybrid Distraction Appliance: a Systematic Review. Journal of Oral and Maxillofacial Research 9(3): E1, 2018

CKIP-1 silencing promotes new bone formation in rat mandibular distraction osteogenesis. Oral Surgery Oral Medicine Oral Pathology and Oral Radiology 123(1): E1-E9, 2017

Effects of latency and rate on bone formation in a porcine mandibular distraction model. Journal of Oral and Maxillofacial Surgery 58(5): 507, 2000