EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Efflux-mediated drug resistance in bacteria: an update



Efflux-mediated drug resistance in bacteria: an update



Drugs 69(12): 1555-1623



Drug efflux pumps play a key role in drug resistance and also serve other functions in bacteria. There has been a growing list of multidrug and drug-specific efflux pumps characterized from bacteria of human, animal, plant and environmental origins. These pumps are mostly encoded on the chromosome, although they can also be plasmid-encoded. A previous article in this journal provided a comprehensive review regarding efflux-mediated drug resistance in bacteria. In the past 5 years, significant progress has been achieved in further understanding of drug resistance-related efflux transporters and this review focuses on the latest studies in this field since 2003. This has been demonstrated in multiple aspects that include but are not limited to: further molecular and biochemical characterization of the known drug efflux pumps and identification of novel drug efflux pumps; structural elucidation of the transport mechanisms of drug transporters; regulatory mechanisms of drug efflux pumps; determining the role of the drug efflux pumps in other functions such as stress responses, virulence and cell communication; and development of efflux pump inhibitors. Overall, the multifaceted implications of drug efflux transporters warrant novel strategies to combat multidrug resistance in bacteria.

(PDF emailed within 0-6 h: $19.90)

Accession: 052911915

Download citation: RISBibTeXText

PMID: 19678712

DOI: 10.2165/11317030-000000000-00000



Related references

Efflux Pump Inhibitors: A Novel Approach to Combat Efflux-Mediated Drug Resistance in Bacteria. Current Drug Targets 17(6): 702-719, 2015

Efflux-mediated drug resistance in bacteria. Drugs 64(2): 159-204, 2004

Efflux-mediated drug resistance in Gram-positive bacteria. Current Opinion in Microbiology 4(5): 509-514, 2001

Structural understanding of efflux-mediated drug resistance: potential routes to efflux inhibition. Current Opinion in Pharmacology 4(5): 479-486, 2004

Cellular efflux transporters and the potential role of natural products in combating efflux mediated drug resistance. Frontiers in Bioscience 22(): 732-756, 2016

Estimation of efflux mediated multi-drug resistance and its correlation with expression levels of two major efflux pumps in mycobacteria. Journal of Communicable Diseases 38(3): 246-254, 2007

New methods for the identification of efflux mediated MDR bacteria, genetic assessment of regulators and efflux pump constituents, characterization of efflux systems and screening for inhibitors of efflux pumps. Current Drug Targets 9(9): 760-778, 2008

Drug efflux pump deficiency and drug target resistance masking in growing bacteria. Proceedings of the National Academy of Sciences of the United States of America 106(20): 8215-8220, 2009

Efflux-mediated antibiotics resistance in bacteria. Pathologie-Biologie 52(10): 607-616, 2004

Multi-drug efflux in bacteria as a basis of resistance. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 39: 747, 1999

Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria. Antimicrobial Agents and Chemotherapy 44(9): 2233-2241, 2000

58 Multi-drug resistance efflux pumps in bacteria: how they work?. Journal of Biomolecular Structure & Dynamics 33 Suppl 1: 39-39, 2015

Efflux pumps and drug resistance in gram-negative bacteria. Trends in Microbiology 2(12): 489-493, 1994

The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clinical Microbiology Reviews 28(2): 337-418, 2015

Efflux-mediated resistance to fluoroquinolones in gram-positive bacteria and the mycobacteria. Antimicrobial Agents and ChemoTherapy 44(10): 2595-2599, 2000