+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Electrokinetically driven fluidic transport in integrated three-dimensional microfluidic devices incorporating gold-coated nanocapillary array membranes



Electrokinetically driven fluidic transport in integrated three-dimensional microfluidic devices incorporating gold-coated nanocapillary array membranes



Lab on a Chip 8(10): 1625-1631



Electrokinetically driven fluid transport was evaluated within three-dimensional hybrid nanofluidic-microfluidic devices incorporating Au-coated nanocapillary array membranes (NCAMs). Gold NCAMs, prepared by electroless gold deposition on polymeric track-etched membranes, were susceptible to gas bubble formation if the interfacial potential difference exceeded approximately 2 V along the length of the gold region. Gold membranes were etched to yield 250 microm wide coated regions that overlap the intersection of two orthogonal microfluidic channels in order to minimize gas evolution. The kinetics of electrolysis of water at the opposing ends of the gold region was modeled and found to be in satisfactory agreement with experimental measurements of the onset of gas bubble formation. Conditions to achieve electrokinetic injection across Au-coated NCAMs were identified, with significant reproducible injections being possible for NCAMs modified with this relatively thin gold stripe. Continuous gold films led to suppressed injections and to a variety of ion enrichment/depletion effects in the microfluidic source channel. The suppression of injections was understood through finite element modeling which revealed the presence of a significant electrophoretic velocity component in opposition to electroosmotic flow at the edge of the Au-dielectric regions.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052923738

Download citation: RISBibTeXText

PMID: 18813383

DOI: 10.1039/b805768k


Related references

Electrokinetic control of fluid transport in gold-coated nanocapillary array membranes in hybrid nanofluidic-microfluidic devices. Lab on a Chip 10(10): 1237-1244, 2010

Three-dimensional integrated microfluidic architectures enabled through electrically switchable nanocapillary array membranes. Biomicrofluidics 1(2): 21502, 2007

Fluidic communication between multiple vertically segregated microfluidic channels connected by nanocapillary array membranes. Electrophoresis 29(6): 1237-1244, 2008

Integrated electrokinetically driven microfluidic devices with pH-mediated solid-phase extraction coupled to microchip electrophoresis for preterm birth biomarkers. Electrophoresis 38(13-14): 1743-1754, 2017

Profiling pH gradients across nanocapillary array membranes connecting microfluidic channels. Journal of the American Chemical Society 127(40): 13928-13933, 2005

A programmable and configurable multi-port System-on-Chip for stimulating electrokinetically-driven microfluidic devices. Conference Proceedings 2011: 8361-8364, 2011

Incorporation of a DNAzyme into Au-coated nanocapillary array membranes with an internal standard for Pb(ii) sensing. Analyst 131(1): 41-47, 2006

Electrokinetically operated microfluidic devices for integrated immunoaffinity monolith extraction and electrophoretic separation of preterm birth biomarkers. Analyst 143(1): 224-231, 2017

Enhanced mass transport of electroactive species to annular nanoband electrodes embedded in nanocapillary array membranes. Journal of the American Chemical Society 134(20): 8617-8624, 2012

Microfluidic valves with integrated structured elastomeric membranes for reversible fluidic entrapment and in situ channel functionalization. Lab on a Chip 9(10): 1461-1467, 2009

Fluidic interconnections for microfluidic systems: A new integrated fluidic interconnection allowing plugnplay functionality. Sensors and Actuators B: Chemical 130(2): 947-953, 2008

Integration of nanocapillary arrays into microfluidic devices for use as analyte concentrators. Analyst 128(6): 537-542, 2003

Nanocapillary array interconnects for gated analyte injections and electrophoretic separations in multilayer microfluidic architectures. Analytical Chemistry 75(10): 2224-2230, 2003

Development of a novel electrokinetically driven microfluidic immunoassay for the detection of Helicobacter pylori. Analytica Chimica Acta 543(1-2): 109-116, 2005

Electrokinetically driven microfluidic chips with surface-modified chambers for heterogeneous immunoassays. Analytical Chemistry 73(14): 3400-3409, 2001