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Enantioselective N-heterocyclic carbene catalyzed annulation reactions with imidazolidinones



Enantioselective N-heterocyclic carbene catalyzed annulation reactions with imidazolidinones



Angewandte Chemie 52(51): 13616-13620



Add acetic acid: A highly stereoselective N-heterocyclic carbene (NHC)-catalyzed formal [4+2] annulation between α,β-unsaturated aldehydes and imidazolidinones for the synthesis of imidazoles has been developed. Acetic acid serves as a key additive to achieve high chemoselectivity for the formal [4+2] annulation product.

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Accession: 052953886

Download citation: RISBibTeXText

PMID: 24249661

DOI: 10.1002/anie.201307292


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