+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Enhanced aortic macrophage lipid accumulation and inflammatory response in LDL receptor null mice fed an atherogenic diet



Enhanced aortic macrophage lipid accumulation and inflammatory response in LDL receptor null mice fed an atherogenic diet



Lipids 45(8): 701-711



The effect of an atherogenic diet on inflammatory response and elicited peritoneal macrophage (Mphi) cholesterol accumulation in relation to aortic lesion formation was assessed in LDL receptor null (LDLr-/-) mice. Mice were fed an atherogenic or control diet for 32 weeks. The atherogenic relative to control diet resulted in significantly higher plasma monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6) concentrations, more aortic wall Mphi deposition, higher serum non HDL-cholesterol concentrations and total cholesterol to HDL-cholesterol ratios, and greater accumulation of both aortic free and esterified cholesterol. Elicited peritoneal Mphi selectively accumulated longer chain unsaturated fatty acids in their membrane, independent of the dietary fatty acid profile. Elicited peritoneal Mphi isolated from mice fed the atherogenic relative to control diet had significantly less arachidonic acid levels, accumulated significantly higher esterified cholesterol, had significantly higher mRNA levels and secretion of MCP-1, and mRNA and protein levels of ATP-binding cassette A1. Diet treatment had no significant effect in elicited peritoneal Mphi on TNFalpha and IL-6 mRNA levels and secretion. These data suggest that the atherogenic relative to control diet resulted in higher plasma inflammatory factor concentrations, less favorable lipoprotein profile, higher elicited peritoneal Mphi cholesterol accumulation and inflammatory factor secretion, and more aortic wall Mphi deposition, which in turn were associated with greater aortic cholesterol accumulation.

(PDF emailed within 0-6 h: $19.90)

Accession: 052982173

Download citation: RISBibTeXText

PMID: 20686867

DOI: 10.1007/s11745-010-3454-8


Related references

Effects of repeated Chlamydia pneumoniae inoculations on aortic lipid accumulation and inflammatory response in C57BL/6J mice. Infection and Immunity 73(10): 6458-6466, 2005

Absence of macrophage inflammatory protein-1{alpha} does not impact macrophage accumulation in adipose tissue of diet-induced obese mice. American Journal of Physiology. Endocrinology and Metabolism 299(3): E437-E445, 2010

Preventive effects of magnesium on raised serum lipid peroxide levels and aortic cholesterol deposition in mice fed an atherogenic diet. Magnesium Research 7(1): 31-37, 1994

Induction of hepatic inflammatory and oxidative stress responsive genes by an atherogenic diet segregates with aortic fatty streak formation in mice. Circulation 88(4 PART 2): I267, 1993

Atherogenic diet induced lipid accumulation induced NFB level in heart, liver and brain of Wistar rat and diosgenin as an anti-inflammatory agent. Life Sciences 196: 28-37, 2018

Atherogenic diet induced lipid accumulation induced NFκB level in heart, liver and brain of Wistar rat and diosgenin as an anti-inflammatory agent. Life Sciences 196: 28-37, 2018

Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice. Journal of Clinical Investigation 91(6): 2572-2579, 1993

Ethanol inhibits atherogenic diet-induced activation of aortic nuclear factor kappaB in low density lipoprotein receptor knockout mice. Circulation 102(18 Supplement): II 307, October 31, 2000

Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation. Endocrinology 152(1): 48-58, 2011

Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids 1863(5): 526-537, 2018

Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1863(5): 526-537, 2018

Insulin resistant mice have an atherogenic plasma lipid profile and increased macrophage lipid uptake and deposition. Diabetes 52(Supplement 1): A214, 2003

Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice. Journal of Lipid Research 51(7): 1729-1737, 2010

Hexim1 heterozygosity stabilizes atherosclerotic plaque and decreased steatosis in ApoE null mice fed atherogenic diet. International Journal of Biochemistry and Cell Biology 83: 56-64, 2016

Perilla Oil Decreases Aortic and Hepatic Lipid Accumulation by Modulating Lipogenesis and Lipolysis in High-Fat Diet-Fed Mice. Journal of Medicinal Food 2018, 2018