+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Enhanced apomorphine sensitivity and increased binding of dopamine D2 receptors in nucleus accumbens in prepubertal rats after neonatal blockade of the dopamine D3 receptors by (+)-S14297



Enhanced apomorphine sensitivity and increased binding of dopamine D2 receptors in nucleus accumbens in prepubertal rats after neonatal blockade of the dopamine D3 receptors by (+)-S14297



Synapse 62(1): 40-49



The role of dopamine (DA) D3 receptors is controversial in early developmental stages of specially locomotor activity. Past studies have only tested behavioral changes induced by neonatal administration of nonselective dopamine antagonist such as haloperidol or sulpiride in adult rats. We investigated the role of neonatal blockade of DA D3 receptors at (postnatal day, P1 to P12) using the DA D3 receptor antagonist (+)-S14297 on paradigms related to DA behaviors including locomotor activity in novel environment and after administration of the DA nonspecific agonists d-amphetamine, and apomorphine. Additionally, autoradiographic studies were performed to correlate behavioral alterations with DA D1-like, D2-like, and D3 receptors. All studies were performed at two critical ages, prepubertal (P35) and postpubertal (P60). The quantitative autoradiogaphic study revealed increases in the expression of DA D2-like receptor expression in the nucleus accumbens (NAcc) in prepubertal animals that received the DA D3 antagonist (+)-S14297 at neonatal age. In addition, novel environment and apomorphine administration (0.5 mg/kg, s.c.), induced increases of locomotor activity in prepubertal animals that received the DA D3 antagonist (+)-S14297. Autoradiographic and behavioral results suggest that blockade of DA D3 receptors after birth may mediate different neurodevelopmental aspects of the dopaminergic pathway before and after puberty.

(PDF emailed within 0-6 h: $19.90)

Accession: 052982177

Download citation: RISBibTeXText

PMID: 17957737

DOI: 10.1002/syn.20463


Related references

Enhanced apomorphine sensitivity and increased binding of dopamine D-2 receptors in nucleus accumbens in prepugertal rats after neonatal blockade of the dopamine D-3 receptors by (+)-S14297. Synapse 62(1): 40-49, 2008

Local activation of metabotropic glutamate receptors inhibits the handling-induced increased release of dopamine in the nucleus accumbens but not that of dopamine or noradrenaline in the prefrontal cortex: comparison with inhibition of ionotropic receptors. Journal of Neurochemistry 70(3): 1104-1113, 1998

Blockade of dopamine receptors reverses the behavioral effects of endogenous enkephalins in the Nucleus caudatus but not in the Nucleus accumbens: differential involvement of delta and mu opioid receptors. Psychopharmacology 99(2): 168-175, 1989

Blockade of D-1 dopamine receptors in the medial prefrontal cortex produces delayed effects on pre- and postsynaptic indices of dopamine function in the nucleus accumbens. Synapse 16(2): 104-112, 1994

Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats. Addiction Biology 18(4): 665-677, 2013

Activation of both D1 and D2 dopamine receptors is involved in the increased expression of mu opioid receptor gene in nucleus accumbens following dopamine agonist administration. FASEB Journal 11(3): A211, 1997

Enhanced amphetamine sensitivity and increased expression of dopamine D2 receptors in postpubertal rats after neonatal excitotoxic lesions of the medial prefrontal cortex. Journal of Neuroscience 16(22): 7366-7375, 1996

Differential effects of dopamine depletion on the binding and mRNA levels of dopamine receptors in the shell and core of the rat nucleus accumbens. Molecular Brain Research 25(3-4): 333-343, 1994

Functional interaction of presynaptic cholecystokinin and dopamine receptors modulating dopamine release in the nucleus accumbens of rats. Biogenic Amines 5(5): 363-368, 1988

Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin. Neuropharmacology 52(3): 1034-1043, 2006

Preferential relocation of the N-methyl-D-aspartate receptor NR1 subunit in nucleus accumbens neurons that contain dopamine D1 receptors in rats showing an apomorphine-induced sensorimotor gating deficit. Neuroscience 154(3): 965-977, 2008

Dopamine D(3) receptors modulate evoked dopamine release from slices of rat nucleus accumbens via muscarinic receptors, but not from the striatum. Journal of Pharmacology and Experimental Therapeutics 291(3): 994-998, 1999

Hyperlocomotion and increased dopamine efflux in the rat nucleus accumbens evoked by electrical stimulation of the ventral subiculum: Role of ionotropic glutamate and dopamine D1 receptors. Psychopharmacology 151(2-3): 242-251, 2000

Stimulation of acetylcholine or dopamine receptors in the nucleus accumbens differentially alters dopamine release in the striatum of freely moving rats. European Journal of Pharmacology 303(1-2): 13-19, 1996

Modulation by oestrogen and progesterone of the response to stimulation of dopamine receptors in the entorhinal cortex on dopamine efflux in the nucleus accumbens of OVX rats. British Journal of Pharmacology 117(PROC SUPPL ): 318P, 1996