+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Enhanced choice for viewing cocaine pictures in cocaine addiction

Enhanced choice for viewing cocaine pictures in cocaine addiction

Biological Psychiatry 66(2): 169-176

Individuals with cocaine use disorder (CUD) chose cocaine over nondrug rewards. In two newly designed laboratory tasks with pictures, we document this modified choice outside of a cocaine administration paradigm. Choice for viewing cocaine, pleasant, unpleasant, or neutral pictures--under explicit contingencies (choice made between two fully visible side-by-side images) and under more implicit contingencies (selections made between pictures hidden under flipped-over cards)--was examined in 20 CUD and 20 matched healthy control subjects. Subjects also provided self-reported ratings of each picture's pleasantness and arousal. Under both contingencies, CUD subjects chose to view more cocaine pictures than control subjects, group differences that were not fully explained by the self-reported picture ratings. Furthermore, whereas CUD subjects' choice for viewing cocaine pictures exceeded choice for viewing unpleasant pictures (but did not exceed choice for viewing pleasant pictures, in contrast to their self-reported ratings), healthy control subjects avoided viewing cocaine pictures as frequently as, or even more than, unpleasant pictures. Finally, CUD subjects with the most cocaine viewing selections, even when directly compared with selections of the pleasant pictures, also reported the most frequent recent cocaine use. Enhanced drug-related choice in cocaine addiction can be demonstrated even for nonpharmacologic (pictorial) stimuli. This choice, which is modulated by alternative stimuli, partly transcends self-reports (possibly indicative of a disconnect in cocaine addiction between self-reports and objective behavior) to provide an objective marker of addiction severity. Neuroimaging studies are needed to establish the neural underpinnings of such enhanced cocaine-related choice.

(PDF emailed within 0-6 h: $19.90)

Accession: 052982777

Download citation: RISBibTeXText

PMID: 19358975

DOI: 10.1016/j.biopsych.2009.02.015

Related references

Preclinical Assessment of Lisdexamfetamine as an Agonist Medication Candidate for Cocaine Addiction: Effects in Rhesus Monkeys Trained to Discriminate Cocaine or to Self-Administer Cocaine in a Cocaine Versus Food Choice Procedure. International Journal of Neuropsychopharmacology 18(8): -, 2016

Choice to view cocaine images predicts concurrent and prospective drug use in cocaine addiction. Drug and Alcohol Dependence 130(1-3): 178-185, 2014

Quality of life, needs, and interest among cocaine users: differences by cocaine use intensity and lifetime severity of addiction to cocaine. Substance Use & Misuse 46(4): 390-397, 2011

Enhanced midbrain response at 6-month follow-up in cocaine addiction, association with reduced drug-related choice. Addiction Biology 17(6): 1013-1025, 2013

Effects of extended cocaine access and cocaine withdrawal on choice between cocaine and food in rhesus monkeys. Neuropsychopharmacology: 2, 493-504, 2010

Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats. Drug and Alcohol Dependence 97(3): 207-215, 2007

The effects of tacrine on cocaine self-administration in rats a potential pharmacotherapy for cocaine addiction. Society for Neuroscience Abstracts 26(1-2): Abstract No -293 18, 2000

Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction. Future Medicinal Chemistry 4(2): 137-150, 2012

Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. Journal of Neuroscience 26(24): 6583-6588, 2006

Cocaine addiction Reinstatements induced by cocaine and by a conditioned stimulus are not related. Society for Neuroscience Abstracts 27(2): 1712, 2001

Effects of pergolide on cocaine self-administration in rodents implications for cocaine addiction. Society for Neuroscience Abstracts 26(1-2): Abstract No -675 7, 2000

Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats. Journal of Pharmacology and Experimental Therapeutics 283(2): 592-603, 1997

Development of Fc-Fused Cocaine Hydrolase for Cocaine Addiction Treatment: Catalytic and Pharmacokinetic Properties. Aaps Journal 20(3): 53-53, 2018

Impaired insight in cocaine addiction: laboratory evidence and effects on cocaine-seeking behaviour. Brain 133(Pt 5): 1484-1493, 2010

Identification of cocaine in cocaine-lidocaine mixtures ("rock cocaine") and other illicit cocaine preparations using derivative absorption spectroscopy. Journal of Analytical Toxicology 12(4): 192-196, 1988