EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Erythropoietin and autoimmune neuroinflammation: lessons from experimental autoimmune encephalomyelitis and experimental autoimmune neuritis


Erythropoietin and autoimmune neuroinflammation: lessons from experimental autoimmune encephalomyelitis and experimental autoimmune neuritis



Anatomy and Cell Biology 45(4): 215-220



ISSN/ISBN: 2093-3665

PMID: 23301189

DOI: 10.5115/acb.2012.45.4.215

Erythropoietin (EPO) is known to have numerous biological functions. While its primary function is during haematopoiesis, recent studies have shown that EPO plays important role in cytoprotection, immunomodulation, and antiapoptosis. These secondary functions of EPO are integral to tissue protection following hypoxic injury, ischemia-reperfusion injury, and spinal cord injury in the central nervous system. This review focuses on experimental evidence documenting the neuroprotective effects of EPO in organ-specific autoimmune nervous system disorders such as experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN). In addition, the immunomodulatory role of EPO in the pathogenesis of EAE and EAN animal models of human multiple sclerosis and Guillain-Barré syndrome, respectively, will be discussed.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053028373

Download citation: RISBibTeXText

Related references

Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 58(1): 81-88, 1995

Role of nitric oxide synthase in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis. Immunobiology 186(1-2): 34, 1992

Cytokines as intrinsic and exogenous regulators of pathogenesis in experimental autoimmune encephalomyelitis : Immunoregulation of experimental autoimmune encephalomyelitis. 1998 Enii 149(9): 771-781, 1998

Regulation of experimental autoimmune encephalomyelitis: inhibition of adoptive experimental autoimmune encephalomyelitis by 'recovery-associated suppressor cells'. Journal of Neuroimmunology 53(2): 123-131, 1994

Chemokine regulation of CNS T-cell infiltration in experimental autoimmune encephalomyelitis : Immunoregulation of experimental autoimmune encephalomyelitis. 1998 Enii 149(9): 790-794, 1998

Tumour necrosis factor-alpha and lymphotoxin-alpha in the pathology of experimental autoimmune encephalomyelitis : is either one responsible or is there another ligand-mediating disease? : Immunoregulation of experimental autoimmune encephalomyelitis. 1998 Enii 149(9): 804-810, 1998

Differential cytokine and chemokine production characterizes experimental autoimmune meningitis and experimental autoimmune encephalomyelitis. Clinical Immunology 94(2): 114-124, 2000

Antigen-driven regulation of experimental autoimmune encephalomyelitis : Immunoregulation of experimental autoimmune encephalomyelitis. 1998 Enii 149(9): 759-771, 1998

Bystander suppression in experimental autoimmune encephalomyelitis : where and how does it occur? : Immunoregulation of experimental autoimmune encephalomyelitis. 1998 Enii 149(9): 820-827, 1998

Naked DNA vaccination differentially modulates autoimmune responses in experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 111(1-2): 34-44, 2000

Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis. Plos one 3(11): E3682, 2008

Inhibitory role of diazepam on autoimmune inflammation in rats with experimental autoimmune encephalomyelitis. Neuroscience 199: 421-428, 2011

Immunosuppression by gramicidin S of experimental autoimmune uveoretinitis, pinealitis and autoimmune encephalomyelitis. Journal of Ocular Pharmacology 6(3): 219-226, 1990

Cytokines as Mediators of Neuroinflammation in Experimental Autoimmune Encephalomyelitis. Biochemistry. Biokhimiia 83(9): 1089-1103, 2018

Enhanced costimulation by CD70+ B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice. Journal of Neuroimmunology 255(1-2): 8-17, 2013