+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Erythropoietin production by a hepatic adenoma in a patient with severe erythrocytosis



Erythropoietin production by a hepatic adenoma in a patient with severe erythrocytosis



Acta Haematologica 121(1): 52-55



A 53-year-old woman with severe erythrocytosis (hemoglobin concentration 19.5 g/dl and hematocrit 0.59) was admitted to our hospital because of fatigue and headache. The serum erythropoietin (Epo) concentration was 68.6 U/l (reference range; 3.7-31.5). Further investigations excluded polycythemia vera or any lung or heart disease. Radiological examination showed a tumor in the left hepatic lobe. Needle biopsies were performed and the histopathological diagnosis was hepatocellular adenoma. Immunohistochemistry demonstrated erythropoietin expression in the adenomatous cells. Liver adenoma is a rare cause of erythrocytosis. For the first time, we report erythropoietin-positive immunoreactivity in liver adenomatous cells in a patient with erythrocytosis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053028668

Download citation: RISBibTeXText

PMID: 19339771

DOI: 10.1159/000210556


Related references

Production of erythropoietin and multiple cytokines by metanephric adenoma results in erythrocytosis. Pathology International 57(8): 529-536, 2007

Erythrocytosis in a patient with hepatocellular carcinoma and alcoholic liver cirrhosis: Ectopic production of erythropoietin. Recenti Progressi in Medicina 89(5): 250-257, 1998

Regulation of erythropoietin production in a case of congenital erythropoietin-dependent pure erythrocytosis. American Journal of Hematology 46(4): 348-353, 1994

Erythropoietin and erythropoietin receptor system in a large uterine myoma of a patient with myomatous erythrocytosis syndrome: possible relationship with the pathogenesis of unusual tumor size. Human Pathology 36(1): 120-127, 2005

Erythrocytosis in a child with a hepatic adenoma. Medical and Pediatric Oncology 36(6): 659-661, 2001

Erythropoietin-dependent erythrocytosis associated with hepatic angiosarcoma. Journal of Surgical Oncology 20(2): 105-108, 1982

Familial erythrocytosis with erythropoietin over production. Experimental Hematology 11(Suppl. 14): 60, 1983

Familial erythrocytosis with over-production of erythropoietin. Clinical and Laboratory Haematology 5(4): 335-342, 1983

Erythrocytosis due to autonomous erythropoietin production by a hypernephroma. Central African Journal of Medicine 49(11-12): 138-140, 2004

Heterogeneity of erythropoietin-dependent erythrocytosis: case report in a child and synopsis of primary erythrocytosis syndromes. British Journal of Haematology 60(4): 751-758, 1985

Paraneoplastic erythrocytosis and inappropriate erythropoietin production. A review. Scandinavian Journal of Haematology. Supplementum 17: 1-166, 1972

Erythropoietin synthesis by tumour tissues in a patient with uterine myoma and erythrocytosis. British Journal of Haematology 113(1): 49-51, 2001

Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal, and muscular degeneration. American Journal of Physiology. Regulatory Integrative and Comparative Physiology 291(4): R947-R956, 2006

Autosomal Dominant familial erythrocytosis due to autonomous erythropoietin production. Blood 58(6): 1155-1158, 1981

Erythrocytosis in renal transplant recipients site of production of erythropoietin. Clinical Research 30(2): 450A, 1982