+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Evidence of person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus in a hematology unit

Evidence of person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus in a hematology unit

Journal of Infectious Diseases 203(1): 18-24

We describe the first confirmed person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus that occurred in a hematology unit in the United Kingdom. Eleven cases of (H1N1) 2009 virus infection were identified, of which, ten were related as shown by sequence analysis of the hemagglutinin and neuraminidase genes. H275Y analysis demonstrated that 8 of 10 case patients had oseltamivir-resistant virus, with 4 of 8 case patients infected by direct transmission of resistant virus. Zanamivir should be considered as first-line therapy for influenza in patients with lymphopenic hematological conditions and uptake of influenza vaccination encouraged to further reduce the number of susceptible individuals.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053097413

Download citation: RISBibTeXText

PMID: 21148492

DOI: 10.1093/infdis/jiq007

Related references

Person-to-person transmission of oseltamivir-resistant influenza A/H1N1 viruses in two households; Germany 2007/08. Journal of Clinical Virology 46(3): 295-297, 2009

Prevalence of Oseltamivir-Resistant 2009 H1N1 Influenza Virus among Patients with Pandemic 2009 H1N1 Influenza infection in NRITLD, Tehran, Iran. Tanaffos 10(1): 8, 2011

Oseltamivir-resistant variants of the 2009 pandemic H1N1 influenza A virus are not attenuated in the guinea pig and ferret transmission models. Journal of Virology 84(21): 11219-11226, 2010

Oseltamivir-resistant pandemic (H1N1) 2009 influenza virus, October 2009. Releve Epidemiologique Hebdomadaire 84(44): 453-459, 2009

Oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus. Annales Francaises D'anesthesie et de Reanimation 29(2): 85-86, 2010

Oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus in Northern Greece. Hippokratia 15(3): 272-274, 2011

Oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection in two summer campers receiving prophylaxis--North Carolina, 2009. Mmwr. Morbidity and Mortality Weekly Report 58(35): 969-972, 2009

The emergence of oseltamivir-resistant pandemic influenza A (H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009. Euro Surveillance 15(14):, 2010

Cluster of oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infections on a hospital ward among immunocompromised patients--North Carolina, 2009. Journal of Infectious Diseases 203(6): 838-846, 2011

Update on oseltamivir-resistant pandemic A (H1N1) 2009 influenza virus: January 2010. Releve Epidemiologique Hebdomadaire 85(6): 37-40, 2010

Adamantane- and oseltamivir-resistant seasonal A (H1N1) and pandemic A (H1N1) 2009 influenza viruses in Guangdong, China, during 2008 and 2009. Journal of Clinical Microbiology 49(7): 2651-2655, 2011

Mammalian pathogenesis of oseltamivir-resistant pandemic (H1N1) 2009 influenza virus isolated in South Korea. Virus Research 185: 41-46, 2014

Oseltamivir-resistant influenza A(H1N1) 2009 virus in Greece during the post-pandemic 2010-2011 season. International Journal of Antimicrobial Agents 40(1): 72-74, 2012

Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets. Plos Pathogens 6(7): E1001022, 2010