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Expression and functional characterisation of the putative SARS coronavirus non-structural proteins X1-X5

Expression and functional characterisation of the putative SARS coronavirus non-structural proteins X1-X5

Hong Kong Medical Journal 14(Suppl. 4): 4-7

1. We produced mammalian expression vectors encoding the SARS coronavirus (SARS-CoV) accessory proteins with or without the fluorescence protein tag and cell lines with stable expression of these proteins. 2. The cellular localisation and function of the SARS-CoV accessory proteins was determined. 3. SARS 6 and SARS 8b proteins are localised to the endoplasmic reticulum and nucleus/cytoplasm, respectively, and both proteins stimulate host cell DNA synthesis.

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Accession: 053147059

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PMID: 18708666

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