+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients



Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients



Open Dentistry Journal 8: 136-143



Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27(Kip1) has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27(Kip1) with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27(Kip1) suggests that also in combination these would not help to better predict the outcome of HNSCC.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 053155969

Download citation: RISBibTeXText

PMID: 25246990


Related references

Relation of E-cadherin and P-cadherin expression in head and neck squamous cell carcinoma to patient prognosis. Pathology Research & Practice 193(5-6): 336, 1997

Expression of E-cadherin and vimentin correlates with metastasis formation in head and neck squamous cell carcinoma patients. RadioTherapy and Oncology 99(3): 344-348, 2011

E-cadherin expression in squamous cell carcinoma of the head and neck. Journal of Pathology 168(Suppl. ): 120A, 1992

E-cadherin expression in head and neck squamous cell carcinoma. Proceedings of the American Association for Cancer Research Annual Meeting 34: 32, 1993

E-cadherin and desmoglein expression in squamous cell carcinoma of head and neck. Journal of Pathology 178(Suppl. ): 34A, 1996

The expression of Ets, E-cadherin and Ki-67 in head and neck squamous cell carcinoma. An immunohistochemical study. 2007

E-Cadherin expression in head and neck squamous-cell carcinoma is associated with clinical outcome. International Journal Of Cancer. 55(4): 580-585, 1993

Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma (HNSCC). Journal of Experimental and Clinical Cancer Research 25(1): 5, 2006

Expression of the cell-cell adhesion molecule E-cadherin in squamous cell carcinoma of the head and neck. Clinical Otolaryngology and Allied Sciences 18(3): 196-201, 1993

E-cadherin expression and prognosis of head and neck squamous cell carcinoma: evidence from 19 published investigations. Oncotargets and Therapy 9: 2447-2453, 2016

Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma. Journal of Experimental and Clinical Cancer Research 33: 40, 2014

Inhibitory effect of p27KIP1 gene transfer on head and neck squamous cell carcinoma cell lines. Head and Neck 25(1): 44-49, 2003

Distinctive E-cadherin and epidermal growth factor receptor expression in metastatic and nonmetastatic head and neck squamous cell carcinoma: predictive and prognostic correlation. Cancer 113(1): 97, 2008

Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma: prognostic implications. Oncology Reports 20(3): 589-595, 2008