Fatty acid synthase and prostate cancer
Wang, K.-F.; Wu, B.
Zhonghua Nan Ke Xue 14(8): 740-742
2008
ISSN/ISBN: 1009-3591 PMID: 18817351 Accession: 053217027
The over expression of fatty acid synthase (FAS), a key enzyme in biosynthesis of fatty acid, can enhance enzyme activity and result in the malignant behavior, special material metabolism and energy metabolism of tumors. The expression of FAS is significantly higher in prostate cancer than in normal prostate tissues, which shows that FAS can be used as a marker in the early diagnosis of prostate cancer. The abnormally increased expression of FAS in prostate cancer may offer a new target for the drug treatment of the disease.
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Related References
Myers, J.S.; von Lersner, A.K.; Sang, Q-Xiang.Amy. 2016: Proteomic Upregulation of Fatty Acid Synthase and Fatty Acid Binding Protein 5 and Identification of Cancer- and Race-Specific Pathway Associations in Human Prostate Cancer Tissues Journal of Cancer 7(11): 1452-1464Qiao, S.; Tuohimaa, P. 2004: Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells Febs Letters 577(3): 451-454
Baron, A.; Migita, T.; Tang, D.; Loda, M. 2004: Fatty acid synthase: a metabolic oncogene in prostate cancer? Journal of Cellular Biochemistry 91(1): 47-53
Pirtskhalaishvili, G.; Mathis, C.; Arlotti, J.A.; Pflug, B.R.; Nelson, J.B. 2002: PET imaging of prostate cancer through manipulation of fatty acid synthase Journal of Urology 167(4 Suppl): 362
Campa, D.; Hüsing, A.; Chang-Claude, J.; Dostal, L.; Boeing, H.; Kröger, J.; Tjønneland, A.; Roswall, N.; Overvad, K.; Dahm, C.C.; Rodríguez, L.; Sala, N.úr.; Pérez, M.J.é S.án.; Larrañaga, N.; Chirlaque, M.-D.; Ardanaz, E.; Khaw, K.-T.; Wareham, N.; Allen, N.E.; Travis, R.C.; Trichopoulou, A.; Naska, A.; Bamia, C.; Palli, D.; Sieri, S.; Tumino, R.; Sacerdote, C.; van Kranen, H.J.; Bas Bueno-de-Mesquita, H.; Stattin, P.är.; Johansson, M.; Chajes, V.; Rinaldi, S.; Romieu, I.; Siddiq, A.; Norat, T.; Riboli, E.; Kaaks, R.; Canzian, F. 2011: Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC) European Journal of Cancer 47(3): 420-427
Campa, D.; Husing, A.; Rodriguez, L.; Sala, N.; Sanchez Perez, M.J.; Larranaga, N.; Chirlaque, M.D.; Ardanaz, E.; Khaw, K.T.; Wareham, N.; Allen, N.E.; Travis, R.C.; Changclaude, J.; Trichopoulou, A.; Naska, A.; Bamia, C.; Palli, D.; Sieri, S.; Tumino, R.; Sacerdote, C. 2011: Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC) European Journal of Cancer (1990) 47(3): 420-427
Shurbaji, M.S.; Kalbfleisch, J.H.; Thurmond, T.S. 1996: Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer Human Pathology 27(9): 917-921
Migita, T.; Ruiz, S.; Fornari, A.; Fiorentino, M.; Priolo, C.; Zadra, G.; Inazuka, F.; Grisanzio, C.; Palescandolo, E.; Shin, E.; Fiore, C.; Xie, W.; Kung, A.L.; Febbo, P.G.; Subramanian, A.; Mucci, L.; Ma, J.; Signoretti, S.; Stampfer, M.; Hahn, W.C.; Finn, S.; Loda, M. 2009: Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer Journal of the National Cancer Institute 101(7): 519-532
Schmidt, L.J.; Ballman, K.V.; Tindall, D.J. 2007: Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride Prostate 67(10): 1111-1120
Graner, E.; Tang, D.; Rossi, S.; Baron, A.; Migita, T.; Weinstein, L.J.; Lechpammer, M.; Huesken, D.; Zimmermann, J.; Signoretti, S.; Loda, M. 2004: The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer Cancer Cell 5(3): 253-261
Madigan, A.A.; Rycyna, K.J.; Parwani, A.V.; Datiri, Y.J.; Basudan, A.M.; Sobek, K.M.; Cummings, J.L.; Basse, P.H.; Bacich, D.J.; O'Keefe, D.S. 2014: Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness American Journal of Pathology 184(8): 2156-2162
De Piano, M.; Manuelli, V.; Zadra, G.; Loda, M.; Muir, G.; Chandra, A.; Morris, J.; Van Hemelrijck, M.; Wells, C.M. 2020: Exploring a role for fatty acid synthase in prostate cancer cell migration Small Gtpases 2020: 1-8
Rae, C.; Haberkorn, U.; Babich, J.W.; Mairs, R.J. 2015: Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy Radiation Research 184(5): 482-493
Huang, M.; Koizumi, A.; Narita, S.; Inoue, T.; Tsuchiya, N.; Nakanishi, H.; Numakura, K.; Tsuruta, H.; Saito, M.; Satoh, S.; Nanjo, H.; Sasaki, T.; Habuchi, T. 2016: Diet-induced alteration of fatty acid synthase in prostate cancer progression Oncogenesis 5: E195
Vāvere, A.L.; Kridel, S.J.; Wheeler, F.B.; Lewis, J.S. 2008: 1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer Journal of Nuclear Medicine: Official Publication Society of Nuclear Medicine 49(2): 327-334
Lau, D.S.Y.; Archer, M.C. 2010: The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells Nutrition and Cancer 62(1): 116-121
Swinnen, J.V.; Roskams, T.; Joniau, S.; Van Poppel, H.; Oyen, R.; Baert, L.; Heyns, W.; Verhoeven, G. 2002: Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer International Journal of Cancer 98(1): 19-22
Qiao, S.; Pennanen, P.; Nazarova, N.; Lou, Y.-R.; Tuohimaa, P. 2003: Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells Journal of Steroid Biochemistry and Molecular Biology 85(1): 1-8
Leisser, A.; Pruscha, K.; Ubl, P.; Wadsak, W.; Mayerhöfer, M.; Mitterhauser, M.; Hacker, M.; Kramer, G.; Shariat, S.; Karanikas, G.; Hartenbach, M.; Haug, A.R. 2015: Evaluation of fatty acid synthase in prostate cancer recurrence: SUV of [(11) C]acetate PET as a prognostic marker Prostate 75(15): 1760-1767
Wen, S.; Niu, Y.; Lee, S.O.; Yeh, S.; Shang, Z.; Gao, H.; Li, Y.; Chou, F.; Chang, C. 2016: Targeting fatty acid synthase with ASC-J9 suppresses proliferation and invasion of prostate cancer cells Molecular Carcinogenesis 55(12): 2278-2290