+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Fluoride effect on the secretory-stage enamel organic extracellular matrix of mice

Fluoride effect on the secretory-stage enamel organic extracellular matrix of mice

Connective Tissue Research 52(3): 212-217

ISSN/ISBN: 0300-8207

PMID: 21117895

DOI: 10.3109/03008207.2010.511731

The formation of an ordered enamel organic extracellular matrix (EOECM) seems to be a crucial step for the proper formation of the enamel mineral phase. The ordered supramolecular structure of the EOECM in the secretory stage can be analyzed using polarizing microscopy, as it is strongly birefringent. Excessive fluoride (F) ingestion during tooth development can cause enamel fluorosis, leading to increased porosity in mature enamel. We analyzed the effects of F on the birefringence of the EOECM in the A/J, CBA, and DBA/2 strains of mice given 0, 11.25, and 45 ppm of fluoride in drinking water. In the CBA and DBA/2 strains, the 11.25 and 45 ppmF groups presented a significant decrease in optical retardation (OR) when compared with the respective 0 (CBA 11.25 ppmF p = 0.0056 and 45 ppmF p < 0.0001; DBA/2 11.25 and 45 ppmF p < 0.05). ORs in A/J 0 ppmF were significantly higher than in 45 (p < 0.0001). The enamel of the A/J strain was more severely affected by fluoride than it was in the other strains of mice and exhibited the lowest levels of fluoride in plasma, whereas its normal secretory enamel presented a significantly higher protein absorbance than it did in CBA and DBA mice (p = 0.0099 and p = 0.0025, respectively). The results showed that experimental fluorosis can alter the supramolecular organization of EOECM in the secretory stage of amelogenesis and that the susceptibility to dental fluorosis seems to be influenced by the inherent characteristics of the developing enamel.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053268363

Download citation: RISBibTeXText

Related references

Amelogenin- and enamelysin (Mmp-20)-deficient mice display altered birefringence in the secretory-stage enamel organic extracellular matrix. Connective Tissue Research 48(1): 39-45, 2007

A study in situ of the effect of metallo- and serine proteinase inhibitors on the birefringence of the secretory stage enamel organic extracellular matrix. Biotechnic and Histochemistry: Official Publication of the Biological Stain Commission 86(2): 108-114, 2011

Ionizing radiation effects on the secretory-stage ameloblasts and enamel organic extracellular matrix. Radiation and Environmental Biophysics 53(3): 589-598, 2014

Birefringence of the secretory-stage enamel organic extracellular matrix from rats submitted to successive injections of bisphosphonates. Connective Tissue Research 51(3): 208-215, 2010

Fluoride effect on organic enamel matrix of developing rat molars. Journal of Dental Research 60(Special Issue): 490, 1981

Effects of fluoride on matrix proteins and their properties in rat secretory enamel. Journal of Dental Research 69(6): 1248-1255, 1990

The in vitro uptake of fluoride by secretory and maturation stage bovine enamel. Journal of Dental Research 67(2): 487-490, 1988

Subunit compartments of secretory stage enamel matrix. Connective Tissue Research 38(1-4): 101-111; Discussion: 139-145, 1998

Subunit Compartments of Secretory Stage Enamel Matrix. Connective Tissue Research 38(1-4): 101-111, 1998

Proteomics of Secretory-Stage and Maturation-Stage Enamel of Genetically Distinct Mice. Caries Research 50(1): 24-31, 2016

Effect of Choline on the Composition and Degradation Enzyme of Extracellular Matrix of Mice Chondrocytes Exposed to Fluoride. Biological Trace Element Research 175(2): 414-420, 2017

Effect of the intraoral fluoride releasing system on enamel enamel solubility tests on bovine permanent enamel treated with low level fluoride solutions. Shika Igaku 51(5): 912-944, 1988

Fluoride-binding by the organic matrix of developing bovine enamel. Archives of Oral Biology 23(4): 285-287, 1978

Amoxicillin diminishes the thickness of the enamel matrix that is deposited during the secretory stage in rats. International Journal of Paediatric Dentistry 26(3): 199-210, 2016

Evidence for amelogenin "nanospheres" as functional components of secretory-stage enamel matrix. Journal of Structural Biology 115(1): 50-59, 1995