+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects



Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects



Nutrients 5(11): 4760-4775



Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this review paper is to show the characteristics of common and severe neural-tube defects together with congenital heart defects (CHD) as vitamin deficiencies play a role in their origin. The findings of the Hungarian intervention (randomized double-blind and cohort controlled) trials indicated that periconceptional folic acid (FA)-containing multivitamin supplementation prevented the major proportion (about 90%) of neural-tube defects (NTD) as well as a certain proportion (about 40%) of congenital heart defects. Finally the benefits and drawbacks of three main practical applications of folic acid/multivitamin treatment such as (i) dietary intake; (ii) periconceptional supplementation; and (iii) flour fortification are discussed. The conclusion arrived at is indeed confirmation of Benjamin Franklin's statement: "An ounce of prevention is better than a pound of care".

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053273519

Download citation: RISBibTeXText

PMID: 24284617

DOI: 10.3390/nu5114760


Related references

Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies. Journal of Obstetrics and Gynaecology Canada 37(6): 534-552, 2015

Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. Journal of Obstetrics and Gynaecology Canada 29(12): 1003-1013, 2007

Recommendations for accelerating global action to prevent folic acid-preventable birth defects and other folate-deficiency diseases: meeting of experts on preventing folic acid-preventable neural tube defects. Birth Defects Research. Part A, Clinical and Molecular Teratology 70(11): 835-837, 2004

Periconceptional folic acid and multivitamin supplementation for the prevention of neural tube defects and other congenital abnormalities. Birth Defects Research. Part A, Clinical and Molecular Teratology 85(4): 260-268, 2009

B12 deficiency identified among women encouraged to take folic acid supplementation for prevention of neural tube defects. Journal of Investigative Medicine 43(SUPPL 1): 91A, 1995

Defining the plasma folate concentration associated with the red blood cell folate concentration threshold for optimal neural tube defects prevention: a population-based, randomized trial of folic acid supplementation. American Journal of Clinical Nutrition 2019, 2019

Prevention of neural tube defects: what is the effect of polymorphism in folate metabolism? Prevention with folic acid and folate. Kinderkrankenschwester 27(9): 385-386, 2008

Evidence of folic acid and folate in the prevention of neural tube defects. Bibliotheca Nutritio et Dieta 2000(55): 192-195, 2000

Neural tube defects in Australia: trends in encephaloceles and other neural tube defects before and after promotion of folic acid supplementation and voluntary food fortification. Birth Defects Research. Part A, Clinical and Molecular Teratology 85(4): 269-273, 2009

Folic acid prevention of neural tube defects Dietary contributions of folate. American Journal of Epidemiology 139(11 SUPPL ): S4, 1994

Folic acid and the prevention of neural tube defects. Folate has potential to cause harm. BMJ 311(6999): 257, 1995

Folic Acid Supplementation for Prevention of Neural Tube Defects. JAMA 317(2): 222, 2017

Folic Acid Supplementation for the Prevention of Neural Tube Defects. Obstetric and Gynecologic Survey 72(5): 259-261, 2017

Folic acid supplementation in the prevention of neural tube defects. Medicina Clinica 118(9): 357; Author Reply 357-8, 2002

Folic acid supplementation and prevention of neural tube defects. Cahiers de Nutrition et de Dietetique 29(2): 92-97, 1994