+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Folate overproduction in Lactobacillus plantarum WCFS1 causes methotrexate resistance



Folate overproduction in Lactobacillus plantarum WCFS1 causes methotrexate resistance



Fems Microbiology Letters 297(2): 261-265



Folate overproduction can serve as a mode of resistance against the folate antagonist methotrexate in Lactobacillus plantarum WCFS1. When compared with a wild-type control strain, an engineered high folate-producing strain was found to be insensitive to methotrexate. The growth rate and the viable count of the folate-overproducing L. plantarum strain were not significantly affected by the presence of methotrexate in the growth medium.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053273620

Download citation: RISBibTeXText

PMID: 19566681

DOI: 10.1111/j.1574-6968.2009.01690.x


Related references

Physiological responses to folate overproduction in Lactobacillus plantarum WCFS1. Microbial Cell Factories 9: 100, 2010

Impact of respiration on resistance of Lactobacillus plantarum WCFS1 to acid stress. Applied and Environmental Microbiology 78(11): 4062-4064, 2012

Effect of respiration and manganese on oxidative stress resistance of Lactobacillus plantarum WCFS1. Microbiology 158(Pt 1): 293-300, 2012

Active Lactobacillus rhamnosus LA68 or Lactobacillus plantarum WCFS1 administration positively influences liver fatty acid composition in mice on a HFD regime. Food and Function 7(6): 2840-2848, 2016

Distinct immunomodulation of bone marrow-derived dendritic cell responses to Lactobacillus plantarum WCFS1 by two different polysaccharides isolated from Lactobacillus rhamnosus LOCK 0900. Applied and Environmental Microbiology 80(20): 6506-6516, 2014

Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis. Food and Function 6(2): 558-565, 2015

Complete genome sequence of Lactobacillus plantarum WCFS1. Proceedings of the National Academy of Sciences of the United States of America 100(4): 1990-1995, 2003

Lactobacillus plantarum WCFS1 electron transport chains. Applied and Environmental Microbiology 75(11): 3580-3585, 2009

The prophage sequences of Lactobacillus plantarum strain WCFS1. Virology 316(2): 5-55, 2003

Unraveling the regulatory network of Lactobacillus plantarum WCFS1. 2007

Characterization of a benzyl alcohol dehydrogenase from Lactobacillus plantarum WCFS1. Journal of Agricultural and Food Chemistry 56(12): 4497-4503, 2008

Functional analysis of Lactobacillus plantarum WCFS1: a proteomic approach. Functional analysis of Lactobacillus plantarum WCFS1: a proteomic approach: 170 pp, 2007

Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome. Journal of Bacteriology 194(1): 195-196, 2012

Molecular characterization of a novel N-acetylneuraminate lyase from Lactobacillus plantarum WCFS1. Applied and Environmental Microbiology 77(7): 2471-2478, 2011