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Formulation development, evaluation and comparative study of effects of super disintegrants in cefixime oral disintegrating tablets

Remya, K.; Beena, P.; Bijesh, P.; Sheeba, A.

Journal of young pharmacists: JYP 2(3): 234-239

2010


ISSN/ISBN: 0975-1505
PMID: 21042477
DOI: 10.4103/0975-1483.66794
Accession: 053288404

The present work was aimed at formulation development, evaluation and comparative study of the effects of superdisintegrants in Cefixime 50 mg oral disintegrating tablets. The superdisintegrants used for the present study were sodium starch glycolate and crosscarmellose sodium. The formulated tablets were evaluated for various tableting properties, like hardness, thickness, friability, weight variation, disintegration time and dissolution rate. Comparative evaluation of the above-mentioned parameters established the superiority of the tablets formulated with crosscarmellose sodium to those formulated with sodium starch glycolate.

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