+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Formulation study for orally disintegrating tablet using partly pregelatinized starch binder

Formulation study for orally disintegrating tablet using partly pregelatinized starch binder

Chemical and Pharmaceutical Bulletin 59(8): 959-964

In this study, we aimed to design orally disintegrating tablets by employing a formulation design approach that enables the production of such tablets in the same facilities used for the production of solid dosage forms on an industrial scale. First, we examined the relationships between the types of binders used in the tablets and the properties of orally disintegrating tablets prepared by the wet granulation method. Results revealed that partly pregelatinized starch is a relatively suitable binder for orally disintegrating tablets as it also serves as a disintegrant. Next, we employed a central composite design for 2 factors, namely, corn starch and partly pregelatinized starch, in order to design granules suited for orally disintegrating tablets composed of D-mannitol, corn starch or partly pregelatinized starch. The effects of these 2 factors on 3 types of responses, namely, 50% granule size, compressing index and disintegrating index, were analyzed with a software package, and responses to changes in the factors were predicted. This study investigated the effects of binder type and binder content in orally disintegrating tablets, and provided evidence that the binder exerts a strong influence on tablet properties, and is therefore an important component of orally disintegrating tablets.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053288636

Download citation: RISBibTeXText

PMID: 21804239

DOI: 10.1248/cpb.59.959

Related references

Efficacy of an ondansetron orally disintegrating tablet: a novel oral formulation of this 5-HT(3) receptor antagonist in the treatment of fractionated radiotherapy-induced nausea and emesis. Emesis Study Group for the Ondansetron Orally Disintegrating Tablet in Radiotherapy Treatment. Clinical Oncology ) 11(5): 340-347, 1999

Investigation on the effect of polymer and starch on the tablet properties of lyophilized orally disintegrating tablet. Archives of Pharmacal Research 2015:, 2015

Pharmacokinetic comparison of an orally disintegrating film formulation with a film-coated tablet formulation of sildenafil in healthy Korean subjects: a randomized, open-label, single-dose, 2-period crossover study. Clinical Therapeutics 35(3): 205-214, 2013

Bioequivalence evaluation of pioglitazone orally disintegrating tablet formulation. Diabetes Management 2(5s): 3-11, 2012

Formulation and Taste Masking of Ranitidine Orally Disintegrating Tablet. Iranian Journal of Pharmaceutical Research 15(4): 677-686, 2016

Pharmacokinetics and pharmacodynamics of an orally disintegrating tablet formulation of dexlansoprazole. Therapeutic Advances in Gastroenterology 9(6): 759-769, 2016

A Randomized Phase I Study to Assess the Effect of Alcohol on the Pharmacokinetics of an Extended-release Orally Disintegrating Tablet Formulation of Amphetamine in Healthy Adults. Clinical Therapeutics 39(8): 1695-1705, 2017

Formulation and evaluation of a novel matrix-type orally disintegrating Ibuprofen tablet. Iranian Journal of Pharmaceutical Research 10(3): 469-479, 2011

Design, Formulation, and Physicochemical Evaluation of Montelukast Orally Disintegrating Tablet. International Journal of Preventive Medicine 7: 120, 2016

Evaluation of Chlorpheniramine Maleate microparticles in orally disintegrating film and orally disintegrating tablet for pediatrics. Drug Development and Industrial Pharmacy 40(7): 910-918, 2014

Preparation and evaluation of an orally fast disintegrating tablet formulation containing a hydrophobic drug. Pharmaceutical Development and Technology 20(1): 60-64, 2015

Orally disintegrating tablet of novel salt of antiepileptic drug: formulation strategy and evaluation. European Journal of Pharmaceutics and Biopharmaceutics 85(3 Pt B): 1300-1309, 2013

Formulation study for lansoprazole fast-disintegrating tablet. III. Design of rapidly disintegrating tablets. Chemical and Pharmaceutical Bulletin 51(10): 1121-1127, 2003

Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination. Pharmaceutics 2(1): 1-17, 2010

Zolmitriptan 25 mg orally disintegrating tablet for acute treatment of migraine Part II-patient preference for a new formulation. Neurology 56(8 Suppl. 3): A357-A358, 2001