+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Frequency of sickle cell genotype among the Yorubas in Lagos: implications for the level of awareness and genetic counseling for sickle cell disease in Nigeria



Frequency of sickle cell genotype among the Yorubas in Lagos: implications for the level of awareness and genetic counseling for sickle cell disease in Nigeria



Journal of Community Genetics 2(1): 13-18



The frequency of sickle cell genotype (HbSHbS) among the Yorubas living in Lagos, Nigeria, was determined. Seven hundred fifteen (715) subjects of different age groups took part in the study after filling consent forms and questionnaires. The haemoglobin genotype of each subject was determined by the usual electophoretic method from blood sample (3.0 ml) obtained from the antecubital vein. Normal and sickle cell haemoglobin genotypes were detected in subjects within the age group 1-50 years such that 366 (73.1%) had HbAHbA genotype, 123(24.5%) had HbAHbS, while 12 (2.4%) had HbSHbS giving genotypic frequencies that were not significantly different from Hardy-Weinberg expectations (P > 0.05). More than half (58.3%) of the subjects with the HbSHbS were in the 11-30 years age group. The results of this study showed that there is need for more awareness campaign and proper genetic counselling about sickle cell disease in Nigeria. This is particularly so for adolescents since they are likely to constitute the majority of intending couples and, therefore, those that will produce genes that will make up the gene pool for future generations. In situations where pregnancy had occurred before the actual marriage (as is sometimes the case), the importance of proper prenatal diagnosis and genetic counselling for sickle cell disorder cannot be overemphasized.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053303618

Download citation: RISBibTeXText

PMID: 22109719

DOI: 10.1007/s12687-010-0033-x


Related references

Level of awareness of genetic counselling in Lagos, Nigeria: its advocacy on the inheritance of sickle cell disease. African Journal of Biotechnology 6(24): 2758-2765, 2007

Knowledge and awareness of personal sickle cell genotype among parents of children with sickle cell disease in southeast Nigeria. Journal of Community Genetics 6(4): 369-374, 2015

Prevalence of Priapism and Its Awareness amongst Male Homozygous Sickle Cell Patients in Lagos, Nigeria. Advances in Urology 2013: 890328, 2013

University students in Nigeria: knowledge, attitude toward sickle cell disease, and genetic counseling before marriage. International Quarterly of Community Health Education 26(1): 85-93, 2007

The pattern of sickle cell disease in pregnancy in Lagos, Nigeria. West African Journal of Medicine 12(2): 96, 1993

Steady state hemoglobin concentration and packed cell volume in homozygous sickle cell disease patients in Lagos, Nigeria. Caspian Journal of Internal Medicine 3(2): 405-409, 2012

Screening and genetic counseling programs for sickle cell trait and sickle cell anemia. Journal of the American Medical Women's Association 29(9): 406-410, 1974

Head circumference of children with sickle cell disease in Lagos, Nigeria. Pan African Medical Journal 25: 4, 2016

Pregnancy outcome in HbSS-sickle cell disease in Lagos, Nigeria. West African Journal of Medicine 21(1): 19-23, 2002

Serum ferritin levels in adults with sickle cell disease in Lagos, Nigeria. Journal of Blood Medicine 4: 59-63, 2013

Spectrum of musculo-skeletal disorders in sickle cell disease in Lagos, Nigeria. Journal of Orthopaedic Surgery and Research 5: 2, 2010

Sickle cell anaemia: awareness among health professionals and medical students at the Lagos University Teaching Hospital, Lagos. Nigerian Quarterly Journal of Hospital Medicine 19(4): 195-199, 2010

Pattern of chronic lung lesions in adults with sickle cell disease in Lagos, Nigeria. Caspian Journal of Internal Medicine 4(4): 754-758, 2013

Living with sickle cell disease and depression in Lagos, Nigeria: A mixed methods study. Social Science and Medicine 161: 27-36, 2016

Electrocardiographic Study in Adult Homozygous Sickle Cell Disease Patients in Lagos, Nigeria. Journal of Tropical Medicine 2016: 4214387, 2016