+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Full evaporation headspace gas chromatography for sensitive determination of high boiling point volatile organic compounds in low boiling matrices

Full evaporation headspace gas chromatography for sensitive determination of high boiling point volatile organic compounds in low boiling matrices

Journal of Chromatography. a 1315: 167-175

Determination of volatile organic components (VOC's) is often done by static headspace gas chromatography as this technique is very robust and combines easy sample preparation with good selectivity and low detection limits. This technique is used nowadays in different applications which have in common that they have a dirty matrix which would be problematic in direct injection approaches. Headspace by nature favors the most volatile compounds, avoiding the less volatile to reach the injector and column. As a consequence, determination of a high boiling solvent in a lower boiling matrix becomes challenging. Determination of VOCs like: xylenes, cumene, N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), N,N-dimethylacetamide (DMA), N-methyl-2-pyrrolidone (NMP), 1,3-dimethyl-2-imidazolidinone (DMI), benzyl alcohol (BA) and anisole in water or water soluble products are an interesting example of the arising problems. In this work, a headspace variant called full evaporation technique is worked out and validated for the mentioned solvents. Detection limits below 0.1 μg/vial are reached with RSD values below 10%. Mean recovery values ranged from 92.5 to 110%. The optimized method was applied to determine residual DMSO in a water based cell culture and DMSO and DMA in tetracycline hydrochloride (a water soluble sample).

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053316828

Download citation: RISBibTeXText

PMID: 24103808

DOI: 10.1016/j.chroma.2013.09.058

Related references

Determination of lower boiling point volatile compounds in beer by headspace gas chromatography collaborative trial. Journal of the Institute of Brewing 95(4): 267-270, 1989

Determination of volatile organic compounds in eucalyptus fast pyrolysis bio-oil by full evaporation headspace gas chromatography. Talanta 176: 47-51, 2018

Evaluation of the full evaporation technique for quantitative analysis of high boiling compounds with high affinity for apolar matrices. Journal of Chromatography. a 1348: 63-70, 2014

Size-exclusion chromatography for the determination of the boiling point distribution of high-boiling petroleum fractions. Journal of Separation Science 38(5): 741-748, 2015

Recovery of volatile organic compounds condensed out of waste gas-streams by selected high boiling point extractants. Journal of Chemical Technology & Biotechnology 67(4): 397-403, 1996

Recovery of waste volatile organic compounds condensed from beverage off-gas by recyclable high-boiling point extractants. Journal of the American Society of Brewing Chemists 55(1): 11-15, 1997

Toxicity to insects of volatile organic compounds in relation to boiling point. Technical Report CSIRO Division of Entomology ( 70): 29 pp., 1996

Optimizations of packed sorbent and inlet temperature for large volume-direct aqueous injection-gas chromatography to determine high boiling volatile organic compounds in water. Journal of Chromatography. a 1356: 221-229, 2014

Liquid paraffin as new dilution medium for the analysis of high boiling point residual solvents with static headspace-gas chromatography. Journal of Pharmaceutical and Biomedical Analysis 55(5): 1017-1023, 2011

A full evaporation headspace technique with capillary GC and ITD: a means for quantitating volatile organic compounds in biological samples. Journal of Chromatographic Science 34(7): 314-319, 1996

A direct headspace sampling technique to rapidly measure low boiling point volatile terpenoids in carrots. Hortscience 32(4): 714-716, 1997

Method and composition for chemical synthesis on an open environment support surface using high boiling point organic solvents to control evaporation. Official Gazette of the United States Patent & Trademark Office Patents 1254(2), 2002

Pyrolysis gas chromatography mass spectrometry of soil humic fractions part 2 the high boiling point compounds. Soil Science Society of America Journal 43(2): 309-312, 1979

Determination of two chlorinated volatile organic compounds in soils by headspace gas chromatography and purge-and-trap gas chromatography mass spectrometry. Pages 135-145 1993, 1993

Influence of cider-making technology on low-boiling-point volatile compounds. Zeitschrift Fuer Lebensmittel-Untersuchung Und Forschung. 6: 522-524, 1993