+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Functional correlates of central white matter maturation in perinatal period in rabbits

Functional correlates of central white matter maturation in perinatal period in rabbits

Experimental Neurology 261: 76-86

Anisotropy indices derived from diffusion tensor imaging (DTI) are being increasingly used as biomarkers of central WM structural maturation, myelination and even functional development. Our hypothesis was that the rate of functional changes in central WM tracts directly reflects rate of changes in structural development as determined by DTI indices. We examined structural and functional development of four major central WM tracts with different maturational trajectories, including internal capsule (IC), corpus callosum (CC), fimbria hippocampi (FH) and anterior commissure (AC). Rabbits were chosen due to perinatal brain development being similar to humans, and four time points were studied: P1, P11, P18 and adults. Imaging parameters of structural maturation included fractional anisotropy (FA), mean and directional diffusivities derived from DTI, and T2 relaxation time. Axonal composition and degree of myelination were confirmed on electron microscopy. To assess functional maturation, conduction velocity was measured in myelinated and non-myelinated fibers by electrophysiological recordings of compound action potential in perfused brain slices. Diffusion indices and T2 relaxation time in rabbits followed a sigmoid curve during development similar to that for humans, with active changes even at premyelination stage. The shape of the developmental curve was different between the fiber tracts, with later onset but steeper rapid phase of development in IC and FH than in CC. The structural development was not directly related to myelination or to functional development. Functional properties in projection (IC) and limbic tracts (FH) matured earlier than in associative and commissural tracts (CC and AC). The rapid phase of changes in diffusion anisotropy and T2 relaxation time coincided with the development of functional responses and myelination in IC and FH between the second and third weeks of postnatal development in rabbits. In these two tracts, MRI indices could serve as surrogate markers of the early stage of myelination. However, the discordance between developmental change of diffusion indices, myelination and functional properties in CC and AC cautions against equating DTI index changes as biomarkers for myelination in all tracts.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053323915

Download citation: RISBibTeXText

PMID: 24997240

DOI: 10.1016/j.expneurol.2014.06.021

Related references

Maturation-dependent vulnerability of perinatal white matter in premature birth. Stroke 38(2 Suppl): 724-730, 2007

Hemodynamic and metabolic correlates of perinatal white matter injury severity. Plos One 8(12): E82940-E82940, 2014

Histopathological correlates of MRI-Defined chronic perinatal white matter injury. 2011

Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury. Annals of Neurology 63(4): 520-530, 2008

Histopathological correlates of magnetic resonance imaging-defined chronic perinatal white matter injury. Annals of Neurology 70(3): 493-507, 2011

A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans. International Journal of Developmental Neuroscience 56: 42-51, 2016

Functional maturation of the neuroendocrine system in the perinatal period: studies of the somatotropic axis in the ovine fetus. Journal of Developmental Physiology 6(3): 301-312, 1984

Cerebral white matter injuries following a hypoxic/ischemic insult during the perinatal period: pathophysiology, prognostic factors, and future strategy of treatment approach. A minireview. Current Pharmaceutical Design 21(11): 1418-1425, 2016

In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism. Alcoholism Clinical & Experimental Research 24(8): 1214-1221, August, 2000

White matter hyperintensities in migraine: Clinical significance and central pulsatile hemodynamic correlates. Cephalalgia 333102417728751-333102417728751, 2017

Metabolic changes in brain white matter after perinatal white matter injury. Pediatric Research 47(4 Part 2): 459A, April, 2000

White matter integrity of central executive network correlates with enhanced brain reactivity to smoking cues. Human Brain Mapping 38(12): 6239-6249, 2017

Involvement of sodium channels in anoxic injury in mammalian central nervous system white matter Ultrastructural correlates. Society for Neuroscience Abstracts 18(1-2): 1586, 1992

Autistic traits in neurotypical adults: correlates of graph theoretical functional network topology and white matter anisotropy patterns. Plos One 8(4): E60982-E60982, 2013

Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume. Neurobiology of Aging 54: 199-213, 2017