+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Genome-wide association mapping for female fertility traits in Danish and Swedish Holstein cattle



Genome-wide association mapping for female fertility traits in Danish and Swedish Holstein cattle



Animal Genetics 41(6): 579-588



A genome-wide association study was conducted using a mixed model analysis for QTL for fertility traits in Danish and Swedish Holstein cattle. The analysis incorporated 2,531 progeny tested bulls, and a total of 36,387 SNP markers on 29 bovine autosomes were used. Eleven fertility traits were analyzed for SNP association. Furthermore, mixed model analysis was used for association analyses where a polygenic effect was fitted as a random effect, and genotypes at single SNPs were successively included as a fixed effect in the model. The Bonferroni correction for multiple testing was applied to adjust the significance threshold. Seventy-four SNP-trait combinations showed chromosome-wide significance, and five of these were significant genome-wide. Twenty-four QTL regions on 14 chromosomes were detected. Strong evidence for the presence of QTL that affect fertility traits were observed on chromosomes 3, 5, 10, 13, 19, 20, and 24. The QTL intervals were generally smaller than those described in earlier linkage studies. The identification of fertility trait-associated SNPs and mapping of the corresponding QTL in small chromosomal regions reported here will facilitate searches for candidate genes and candidate polymorphisms.

(PDF emailed within 0-6 h: $19.90)

Accession: 053395871

Download citation: RISBibTeXText

PMID: 20477799

DOI: 10.1111/j.1365-2052.2010.02064.x


Related references

Genome-wide association study for calving traits in Danish and Swedish Holstein cattle. Journal of Dairy Science 94(1): 479-486, 2011

Genome scan detects quantitative trait loci affecting female fertility traits in Danish and Swedish Holstein cattle. Journal of Dairy Science 92(5): 2136-2143, 2009

Genome-wide association for milk production and female fertility traits in Canadian dairy Holstein cattle. Bmc Genetics 17(1): 75, 2017

Genome-wide association study for lactation persistency, female fertility, longevity, and lifetime profit index traits in Holstein dairy cattle. Journal of Dairy Science 100(2): 1246-1258, 2016

Genome-wide mapping of 10 calving and fertility traits in Holstein dairy cattle with special regard to chromosome 18. Journal of Dairy Science 100(3): 1987-2006, 2017

Genome-wide association and biological pathway analysis for milk-fat composition in Danish Holstein and Danish Jersey cattle. Bmc Genomics 15: 1112, 2016

Genome wide analysis of fertility and production traits in Italian Holstein cattle. Plos One 8(11): E80219, 2014

Joint genome-wide association study for milk fatty acid traits in Chinese and Danish Holstein populations. Journal of Dairy Science 98(11): 8152-8163, 2016

Genome-wide association studies of fertility and calving traits in Brown Swiss cattle using imputed whole-genome sequences. Bmc Genomics 18(1): 910, 2018

Genome-wide association study for calving traits in Holstein-Friesian dairy cattle. Animal 8(2): 224-235, 2014

A genome-wide association study of immune response traits in Canadian Holstein cattle. Bmc Genomics 15: 559, 2015

Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis. Animal Genetics 42(3): 263-269, 2011

Genome wide association studies for body conformation traits in the Chinese Holstein cattle population. Bmc Genomics 14: 897, 2014

Comparing power and precision of within-breed and multibreed genome-wide association studies of production traits using whole-genome sequence data for 5 French and Danish dairy cattle breeds. Journal of Dairy Science 99(11): 8932-8945, 2016

Genome-wide association study identifies candidate markers for bull fertility in Holstein dairy cattle. Animal Genetics 43 Suppl 1: 65-71, 2012