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Gold(I)-catalyzed intramolecular enantioselective hydroarylation of allenes with indoles



Gold(I)-catalyzed intramolecular enantioselective hydroarylation of allenes with indoles



Organic Letters 9(10): 1935-1938



Treatment of 2-allenyl indole 4 with a catalytic 1:2 mixture of [(S)-2]Au2Cl2 [(S)-2 = (S)-3,5-tBu-4-MeO-MeOBIPHEP] and AgBF4 in toluene at -10 degrees C for 17 h led to isolation of tetrahydrocarbazole 5 in 88% yield with 92% ee. The protocol was effective for the cyclization of terminally disubstituted allenes and for the formation of seven-membered rings.

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Accession: 053432738

Download citation: RISBibTeXText

PMID: 17428061

DOI: 10.1021/ol070483c


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