+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Haemodynamics and acid-base equilibrium after cardiac surgery: comparison of rapidly degradable hydroxyethyl starch solutions and albumin

Haemodynamics and acid-base equilibrium after cardiac surgery: comparison of rapidly degradable hydroxyethyl starch solutions and albumin

Scandinavian Journal of Surgery 97(3): 259-265

Stable haemodynamics is often achieved by administration of colloids after cardiac surgery. We conducted a prospective, randomized, open-label study comparing haemodynamics and acid-base equilibrium after infusion of two rapidly degradable hydroxyethyl starch (HES) solutions or human albumin (HA) to cardiac surgical patients. 45 patients received a predetermined fixed dose of 15 ml kg(-1) of either 6% HES (mW 130 kDa, n = 15), 6% HES (MW 200 kDa, n = 15) or 4% HA (MW 69 kDa, n = 15) after on-pump cardiac surgery. Left ventricular filling pressures assessed using pulmonary artery catheter responded similarly in all groups. mean (SD) cardiac index was higher in HES130 [3.5 l min(-1) m(-2) (0.7) ] and HES200 [3.5 l min(-1) m(-2) (0.5)] than in HA [2.8 l min(-1) m(-2) (0.6)] group after completion of infusion (P = 0.002) but no differences were detected at 2 and 18 hours. Oxygen delivery increased in both HES groups but not in HA group. After cessation of infusion base excess was the most negative in Ha group. At 2 hours mean (SD) base excess was higher in HES130 [0 (1.32)] than in HES200 [-1.32 (2.27) ] and HA [-2.3 (1.3)] group (P = 0.002, between the groups). We conclude that the effect of albumin on cardiac performance is inferior than that of HES130 or HES200 in early postoperative phase after cardiac surgery. HES130 induces no alterations in acid-base equilibrium whereas a negative base excess was observed after HA infusion.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 053472139

Download citation: RISBibTeXText

PMID: 18812277

Related references

Rapidly Degradable Hydroxyethyl Starch Solutions Impair Blood Coagulation After Cardiac Surgery. Survey of Anesthesiology 54(1): 5-6, 2010

Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trial. Anesthesia and Analgesia 108(1): 30-36, 2009

Comparison of low molecular weight hydroxyethyl starch and human albumin as priming solutions in children undergoing cardiac surgery. Perfusion 29(5): 462-468, 2014

Different effects of fluid loading with saline, gelatine, hydroxyethyl starch or albumin solutions on acid-base status in the critically ill. Plos one 12(4): E0174507, 2017

Acid/base alterations during major abdominal surgery: 6% hydroxyethyl starch infusion versus 5% albumin. Korean Journal of Anesthesiology 71(6): 459-466, 2018

Hemodynamic comparison of albumin and hydroxyethyl starch in postoperative cardiac surgery patients. Critical Care Medicine 11(12): 943-945, 1983

A comparison of the haemodynamic effects of 4% succinylated gelatin, 6% hydroxyethyl starch (200/0.5) and 4% human albumin after cardiac surgery. Scandinavian Journal of Surgery 96(1): 72-78, 2007

Comparison of the effects of albumin 5%, hydroxyethyl starch 130/0.4 6%, and Ringer's lactate on blood loss and coagulation after cardiac surgery. British Journal of Anaesthesia 112(2): 255-264, 2014

Comparison of Albumin, Hydroxyethyl Starch and Ringer Lactate Solution as Priming Fluid for Cardiopulmonary Bypass in Paediatric Cardiac Surgery. Journal of Clinical and Diagnostic Research 10(6): Uc01-Uc04, 2016

Bring rapidly degradable hydroxyethyl starch to the United States. Anesthesiology 104(5): 1105-6; Author Reply 1106, 2006

Albumin utilization in cardiac surgery after transition to hydroxyethyl starch 130/0.4. Journal of Pharmacy Practice 25(6): 606-610, 2012

Gelatin and hydroxyethyl starch, but not albumin, impair hemostasis after cardiac surgery. Anesthesia and Analgesia 102(4): 998-1006, 2006

A comparison between 25% albumin and 6% hydroxyethyl starch solutions on lung water accumulation during and immediately after cardiopulmonary bypass. Annals of Surgery 206(2): 210-213, 1987

Perioperative volume replacement in children undergoing cardiac surgery: albumin versus hydroxyethyl starch 130/0.4. Critical Care Medicine 37(2): 696-701, 2009

Decreased circulating levels of von Willebrand factor after intravenous administration of a rapidly degradable hydroxyethyl starch (HES 200/0.5/6) in healthy human subjects. Intensive Care Medicine 27(11): 1825-1829, 2001