+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Helicobacter  pylori Eradication Therapies in the Era of Increasing Antibiotic Resistance: A Paradigm Shift to Improved Efficacy

Helicobacter  pylori Eradication Therapies in the Era of Increasing Antibiotic Resistance: A Paradigm Shift to Improved Efficacy

Gastroenterology Research and Practice 2012: 757926

With the rising prevalence of antimicrobial resistance, the eradication rates of Helicobacter pylori (H. pylori) with standard treatments are decreasing to unacceptable levels (i.e., ≤80%) in most countries. After these disappointing results, several authorities have proposed that infection with H. pylori should be approached and treated as any other bacterial infectious disease. This implicates that clinicians should prescribe empirical treatments yielding a per protocol eradication of at least 90%. In recent years several treatments producing ≥90% cure rates have been proposed including sequential therapy, concomitant quadruple therapy, hybrid (dual-concomitant) therapy, and bismuth-containing quadruple therapy. These treatments are likely to represent the recommended first-line treatments in the near future. In the present paper, we are considering a series of critical issues regarding currently available means and approaches for the management of H. pylori infection. Clinical needs and realistic endpoints are taken into account. Furthermore, emerging strategies for the eradication of H. pylori and the existing evidence of their clinical validation and widespread applicability are discussed.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053504433

Download citation: RISBibTeXText

PMID: 22778723

DOI: 10.1155/2012/757926

Related references

Efficacy of bismuth containing quadruple therapies on Helicobacter pylori eradication in patients with history of antibiotic treatment. Zhong Nan Da Xue Xue Bao. Yi Xue Ban 43(7): 772-778, 2018

Increasing primary antibiotic resistance and ethnic differences in eradication rates of Helicobacter pylori infection in New Zealand--a new look at an old enemy. New Zealand Medical Journal 126(1384): 64-76, 2013

Comparison of the efficacy of triple versus quadruple therapy on the eradication of Helicobacter pylori and antibiotic resistance. Journal of Digestive Diseases 11(5): 313-318, 2010

Meta-analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori. Alimentary Pharmacology and Therapeutics 26(3): 343-357, 2007

Eradication of Helicobacter pylori infection Side effects during different antibiotic therapies. Gastroenterology 108(4 Suppl. ): A104, 1995

Increasing role for modified bismuth-containing quadruple therapies for Helicobacter pylori eradication. Minerva Gastroenterologica e Dietologica 63(2): 77-79, 2017

The impact of primary antibiotic resistance on the efficacy of ranitidine bismuth citrate- vs. omeprazole-based one-week triple therapies in H. pylori eradication--a randomised controlled trial. Wiener Klinische Wochenschrift 114(12): 448-453, 2002

Efficacy of tailored therapy for Helicobacter pylori eradication based on clarithromycin resistance and survey of previous antibiotic exposure: A single-center prospective pilot study. Helicobacter 24(4): E12585, 2019

Antibiotic susceptibility of Helicobacter pylori in central Germany and its relationship with the number of eradication therapies. European Journal of Gastroenterology and Hepatology 25(11): 1257-1260, 2013

New one-week triple therapies with metronidazole for the eradication of Helicobacter pylori: clarithromycin or amoxycillin as the second antibiotic. Medicina Clinica 110(1): 1-5, 1998

First-line eradication therapy for Helicobacter pylori in primary health care based on antibiotic resistance: results of three eradication regimens. Alimentary Pharmacology & Therapeutics 21(6): 773-782, 2005

Antibiotic resistance in Helicobacter pylori strains and its effect on H. pylori eradication rates in a single center in Korea. Annals of Laboratory Medicine 33(6): 415-419, 2013

Efficacy of quadruple therapies as second-line regimens for eradication of Helicobacter pylori. Zhongguo Xinyao yu Linchuang Zazhi 21(3): 146-148, 2002

Antibiotic resistance and CYP2C19 polymorphisms affect the efficacy of concomitant therapies for Helicobacter pylori infection: an open-label, randomized, single-centre clinical trial. Journal of Antimicrobial ChemoTherapy 71(8): 2280-2285, 2016

Efficacy of different therapies for Helicobacter pylori eradication A 5-year experience in a single center. Gut 51(Suppl. 2): A97, 2002