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Herpes simplex virus 1 counteracts viperin via its virion host shutoff protein UL41

Shen, G.; Wang, K.; Wang, S.; Cai, M.; Li, M.-l.; Zheng, C.

Journal of Virology 88(20): 12163-12166

2014


ISSN/ISBN: 1098-5514
PMID: 25078699
DOI: 10.1128/jvi.01380-14
Accession: 053524260

The interferon (IFN)-inducible viperin protein restricts a broad range of viruses. However, whether viperin plays a role during herpes simplex virus 1 (HSV-1) infection is poorly understood. In the present study, it was shown for the first time that wild-type (WT) HSV-1 infection couldn't induce viperin production, and ectopically expressed viperin inhibited the replication of UL41-null HSV-1 but not WT viruses. The underlying molecular mechanism is that UL41 counteracts viperin's antiviral activity by reducing its mRNA accumulation.

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