+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer



High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer



Future Oncology 8(3): 259-272



Recent advancements in understanding the role of both genetics and molecular pathways in the formation and progression of colorectal cancer have allowed the identification of factors that may be targeted for drug discovery. During the past decade, various approaches have been developed to target specific steps or components of these pathways in order to prevent the development and progression of colorectal cancer and to treat this disease. The innovation and optimization of high-throughput screening methods, as well as the recent emphasis from the NIH on translational sciences, have enabled rapid progress in drug discovery in many fields, including colorectal cancer. Here we present a summary of the recent efforts of targeted high-throughput drug discovery directed at pathways affected in colorectal cancer.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053553023

Download citation: RISBibTeXText

PMID: 22409463

DOI: 10.2217/fon.12.19


Related references

Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening. Molecular Cancer Therapeutics 8(3): 563-570, 2009

High Throughput Screening for Colorectal Cancer Specific Compounds. Combinatorial Chemistry and High Throughput Screening 19(3): 180-188, 2016

Tu1894 Ultrahigh-Throughput Screening Strategies for Identification of Small-Molecule Compounds That Target the Colon Cancer Oncogene KrPpel-Like Factor 5. Gastroenterology 144(5): S-874, 2013

High-throughput siRNA screening as a method of perturbation of biological systems and identification of targeted pathways coupled with compound screening. Methods in Molecular Biology 563: 275-287, 2009

New strategies for target identification, validation, and use of enzymes in high-throughput screening. Kirst, Herbert A , Reprint Author, Yeh, Wu-Kuang, Zmijewski, Milton Joseph Jr Enzyme technologies for pharmaceutical and biotechnological applications: 499-513, 2001

Estimating the Effect of Targeted Screening Strategies: An Application to Colonoscopy and Colorectal Cancer. Epidemiology 28(4): 470-478, 2017

Identification of novel keratinocyte differentiation modulating compounds by high-throughput screening. Journal of Biomolecular Screening 11(8): 977-984, 2006

Identification of cyclic di-GMP protein receptors: high-throughput screening strategies and experimental verification. Sheng Wu Gong Cheng Xue Bao 33(9): 1376-1389, 2017

High-throughput screening for the identification of new therapeutic options for metastatic pheochromocytoma and paraganglioma. Plos one 9(4): E90458, 2014

Identification of ligands targeting RGS proteins high-throughput screening and therapeutic potential. Progress in Molecular Biology and Translational Science 86: 335-356, 2009

High-throughput screening in colorectal cancer tissue-originated spheroids. Cancer Science 110(1): 345-355, 2019

Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method. Cancer 117(7): 1386-1398, 2011

Identification and validation of vesicant therapeutic targets using a high-throughput siRNA screening approach. Archives of Toxicology 90(2): 375-383, 2016

Quantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds. Matrix Biology 31(6): 360-367, 2012

Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform. Current Chemical Genomics and Translational Medicine 8: 36-46, 2014