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Higher genetic susceptibility to inflammation in mild disease activity of systemic lupus erythematosus



Higher genetic susceptibility to inflammation in mild disease activity of systemic lupus erythematosus



Rheumatology International 29(9): 1001-1011



In order to test the hypothesis that stratification of Mexican Modification of the Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI) simplifies the genetic study of SLE, we evaluated the genetic susceptibility to inflammation and defects in clearance of immune complexes among SLE patients in Taiwan. SLE phenotypes were stratified according to the MEX-SLEDAI scores into two subgroups (10), and then according to renal disorder and neurological disorder, aiming to minimize any loss of power associated with disease heterogeneity. Upon stratification, IL1-beta polymorphism and LTA were significantly associated with SLE within the MEX-SLEDAI

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Accession: 053554067

Download citation: RISBibTeXText

PMID: 19399503

DOI: 10.1007/s00296-009-0900-0


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