+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Higher susceptibility of type 1 diabetic rats to Mycobacterium tuberculosis infection



Higher susceptibility of type 1 diabetic rats to Mycobacterium tuberculosis infection



Tohoku Journal of Experimental Medicine 216(4): 363-370



An association between diabetes mellitus and tuberculosis has been implicated for a long time. We have previously reported that Goto Kakizaki type 2 diabetic rats are highly susceptible to Mycobacterium (M.) tuberculosis infection. As a next step, we attempted to clarify whether type 1 diabetic rats are more susceptible to M. tuberculosis than non-diabetic wild-type (WT) rats. Here, we used the Komeda diabetes-prone (KDP) rat, as a model of type 1 diabetes mellitus. The infected KDP rats developed large granulomas without central necrosis in their lungs, liver or spleen. This was consistent with a significant increase in the number of colony-forming units (cfu) of M. tuberculosis in the lungs and spleen (p < 0.01). Insulin treatment resulted in significant reduction of tubercle bacilli in the infected KDP rats (p < 0.01). Pulmonary levels of interferon-gamma, tumor necrosis factor-alpha and interleukin-1beta mRNAs were higher in the infected diabetic rats than in WT rats. Alveolar macrophages from KDP rats were not fully activated by M. tuberculosis infection because the macrophages did not secrete nitric oxide (NO) that can kill M. tuberculosis (p < 0.01), but no significant difference in phagocytosis of tubercle bacilli by alveolar macrophages was observed between KDP and WT rats. Taken together, our findings indicate that type 1 diabetic rats are more susceptible to M. tuberculosis that WT rats.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 053554764

Download citation: RISBibTeXText

PMID: 19060451


Related references

Higher Susceptibility of Type 1 Diabetic Rats to Mycobacterium tuberculosis Infection. The Tohoku Journal of Experimental Medicine 216(4): 363-370, 2008

Diminished systemic and antigen-specific type 1, type 17, and other proinflammatory cytokines in diabetic and prediabetic individuals with latent Mycobacterium tuberculosis infection. Journal of Infectious Diseases 210(10): 1670-1678, 2014

Impaired Cytokine but Enhanced Cytotoxic Marker Expression in Mycobacterium tuberculosis-Induced CD8+ T Cells in Individuals With Type 2 Diabetes and Latent Mycobacterium tuberculosis Infection. Journal of Infectious Diseases 213(5): 866-870, 2016

In vitro susceptibility of Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis, Mycobacterium avium, Mycobacterium fortuitum, and Mycobacterium chelonae to ticarcillin in combination with clavulanic acid. Antimicrobial Agents and ChemoTherapy 31(1): 132-133, 1987

Resistance and Susceptibility to Mycobacterium tuberculosis Infection and Disease in Tuberculosis Households in Kampala, Uganda. American Journal of Epidemiology 187(7): 1477-1489, 2018

Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease. Vaccine 29(1): 51-57, 2010

A new model for chronic and reactivation tuberculosis: Infection with genetically attenuated Mycobacterium tuberculosis in mice with polar susceptibility. Tuberculosis 113: 130-138, 2018

IFNG +874T/A polymorphism and cytokine plasma levels are associated with susceptibility to Mycobacterium tuberculosis infection and clinical manifestation of tuberculosis. Human Immunology 71(7): 692-696, 2010

Tuberculin susceptibility and Mycobacterium tuberculosis infection in children. Problemy Tuberkuleza i Boleznei Legkikh 2007(1): 5-9, 2007

Racial differences in susceptibility to infection by Mycobacterium tuberculosis. New England Journal of Medicine 322(7): 422-427, 1990

Adjuvant arthritis in rats: susceptibility to arthritis induced by Mycobacterium butyricum and Mycobacterium tuberculosis. Transplantation Proceedings 31(3): 1590-1591, 1999

Human ULK1 Variation and Susceptibility to Mycobacterium tuberculosis Infection. Journal of Infectious Diseases 214(8): 1260-1267, 2016

Susceptibility to mycobacterium tuberculosis infection among risk group children. Problemy Tuberkuleza (6): 10-12, 1991

RDRio Mycobacterium tuberculosis infection is associated with a higher frequency of cavitary pulmonary disease. Journal of Clinical Microbiology 46(7): 2175-2183, 2008

Mycobacterium tuberculosis dormancy-associated antigen of Rv2660c induces stronger immune response in latent Mycobacterium tuberculosis infection than that in active tuberculosis in a Chinese population. European Journal of Clinical Microbiology and Infectious Diseases 34(6): 1103-1109, 2015