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Highly regioselective Au(I)-catalyzed hydroamination of ynamides and propiolic acid derivatives with anilines

Highly regioselective Au(I)-catalyzed hydroamination of ynamides and propiolic acid derivatives with anilines

Organic Letters 11(18): 4208-4211

A highly regioselective hydroamination of unsymmetrical electron-poor and electron-rich alkynes with anilines catalyzed by Au(I) under mild conditions is reported. In addition, applications toward indole syntheses are presented including an example of a one-pot synthesis from a nonfunctionalized aniline.

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Accession: 053558748

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PMID: 19697920

DOI: 10.1021/ol901565p

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