+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Histotripsy focal ablation of implanted prostate tumor in an ACE-1 canine cancer model

Histotripsy focal ablation of implanted prostate tumor in an ACE-1 canine cancer model

Journal of Urology 188(5): 1957-1964

Histotripsy is a nonthermal ablative focused ultrasound technology with possible future applications for prostate cancer focal therapy. We used the ACE-1 prostate tumor model and evaluated the feasibility of treating prostate tumors with histotripsy. A total of 10 immunosuppressed (cyclosporine treated) canine subjects received transrectal ultrasound guided percutaneous intraprostatic injection of ACE-1 canine prostate cancer cells. Prostates were serially imaged with transrectal ultrasound to monitor tumor growth. Subjects were sham treated (3) or underwent transabdominal histotripsy of the prostate, which targeted implanted tumor and adjacent parenchyma using a 750 kHz piezoelectric ultrasound therapy transducer. Prostates were examined histologically to confirm tumor and the histotripsy treatment effect. ACE-1 tumors were visualized on transrectal ultrasound in all 10 subjects within 2 weeks of tumor injection. Lesions demonstrated growth in the prostatic capsule, glandular lobules, fibrous septa and periurethral stroma with significant desmoplastic reaction and areas of central necrosis on histology. Lymph node and/or pulmonary metastases developed in 4 subjects. Ultrasound tumor localization and initiation of cavitation during histotripsy therapy were feasible in all treated subjects. Histologically there was evidence of homogenization of tumor and prostatic parenchyma in all 4 acute subjects with necrosis and hemorrhage in the 3 chronic subjects. This study shows the feasibility of histotripsy destruction of prostate tumors in a canine ACE-1 model. It suggests a potential role for histotripsy based focal therapy for prostate cancer. Further studies are needed to better characterize the effects of histotripsy on malignant tissues.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053570572

Download citation: RISBibTeXText

PMID: 22999534

DOI: 10.1016/j.juro.2012.07.006

Related references

V324 Histotripsy Ablation Of The Prostate In A Canine Model. The Journal of Urology 183(4): e128-e129, 2010

Histotripsy of VX-2 tumor implanted in a renal rabbit model. Journal of Endourology 24(7): 1145-1150, 2010

Histotripsy of renal implanted VX-2 tumor in a rabbit model: investigation of metastases. Urology 80(3): 724-729, 2012

Histotripsy of the prostate using a commercial system in a canine model. Journal of Urology 191(3): 860-865, 2014

Urethral-sparing histotripsy of the prostate in a canine model. Urology 80(3): 730-735, 2012

Histotripsy: minimally invasive technology for prostatic tissue ablation in an in vivo canine model. Urology 72(3): 682-686, 2008

Histotripsy of the prostate: dose effects in a chronic canine model. Urology 74(4): 932-937, 2009

Histotripsy of the Prostate in a Canine Model: Characterization of Post-Therapy Inflammation and Fibrosis. Journal of Endourology 29(7): 810-815, 2015

Prostate histotripsy: evaluation of prostatic urethral treatment parameters in a canine model. Bju International 113(3): 498-503, 2014

Endoscopic assessment and prediction of prostate urethral disintegration after histotripsy treatment in a canine model. Journal of Endourology 26(2): 183-189, 2012

Histotripsy fractionation of prostate tissue: local effects and systemic response in a canine model. Journal of Urology 185(4): 1484-1489, 2011

Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer: Genetic Ablation of Cav-1 Delays Advanced Prostate Tumor Development in Tramp Mice. Journal of Urology 175(1): 388-389, 2006

Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice. Journal of Biological Chemistry 280(26): 25134-25145, 2005

Histotripsy for Non-Invasive Ablation of Hepatocellular Carcinoma (HCC) Tumor in a Subcutaneous Xenograft Murine Model. Conference Proceedings 2018: 6064-6067, 2018

Irreversible Electroporation of Prostate Cancer: Patient-Specific Pretreatment Simulation by Electric Field Measurement in a 3D Bioprinted Textured Prostate Cancer Model to Achieve Optimal Electroporation Parameters for Image-Guided Focal Ablation. Cardiovascular and Interventional Radiology 39(11): 1668-1671, 2016