+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Household transmission of 2009 pandemic influenza A (H1N1): a systematic review and meta-analysis



Household transmission of 2009 pandemic influenza A (H1N1): a systematic review and meta-analysis



Epidemiology 23(4): 531-542



During the 2009 influenza A (H1N1) pandemic, household transmission studies were implemented to better understand the characteristics of the transmission of the novel virus in a confined setting. We conducted a systematic review and meta-analysis to assess and summarize the findings of these studies. We identified 27 articles, around half of which reported studies conducted in May and June 2009. In 13 of the 27 studies (48%) that collected respiratory specimens from household contacts, point estimates of the risk of secondary infection ranged from 3% to 38%, with substantial heterogeneity. Meta-regression analyses revealed that a part of the heterogeneity reflected varying case ascertainment and study designs. The estimates of symptomatic secondary infection risk, based on 20 studies identifying febrile acute respiratory illness among household contacts, also showed substantial variability, with point estimates ranging from 4% to 37%. Transmission of the 2009 pandemic virus in households appeared to vary among countries and settings, with differences in estimates of the secondary infection risk also partly due to differences in study designs.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053586194

Download citation: RISBibTeXText

PMID: 22561117

DOI: 10.1097/ede.0b013e31825588b8


Related references

Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: A systematic review and meta-analysis. Vaccine 35(16): 1996-2006, 2017

Immunogenicity and safety of pandemic influenza A (H1N1) 2009 vaccine: systematic review and meta-analysis. Influenza and other Respiratory Viruses 5(5): 299-305, 2011

Serologically confirmed household transmission of 2009 pandemic influenza A (H1N1) virus during the first pandemic wave--New York City, April-May 2009. Clinical Infectious Diseases 53(5): 455-462, 2011

Attack rates assessment of the 2009 pandemic H1N1 influenza A in children and their contacts: a systematic review and meta-analysis. Plos one 7(11): E50228, 2012

Efficacy and effectiveness of seasonal and pandemic A (H1N1) 2009 influenza vaccines in low and middle income countries: a systematic review and meta-analysis. Vaccine 31(45): 5168-5177, 2013

The Occupational Risk of Influenza A (H1N1) Infection among Healthcare Personnel during the 2009 Pandemic: A Systematic Review and Meta-Analysis of Observational Studies. Plos one 11(8): E0162061, 2016

Weight and prognosis for influenza A(H1N1)pdm09 infection during the pandemic period between 2009 and 2011: a systematic review of observational studies with meta-analysis. Infectious Diseases 48(11-12): 813-822, 2017

Household transmission of pandemic 2009 influenza A (H1N1) virus in Osaka, Japan in May 2009. Journal of Infection 61(4): 284-288, 2010

Partial protection against 2009 pandemic influenza A (H1N1) of seasonal influenza vaccination and related regional factors: Updated systematic review and meta-analyses. Human Vaccines and Immunotherapeutics 11(6): 1337-1344, 2015

Impact of neuraminidase inhibitor treatment on outcomes of public health importance during the 2009-2010 influenza A(H1N1) pandemic: a systematic review and meta-analysis in hospitalized patients. Journal of Infectious Diseases 207(4): 553-563, 2013

Secondary household transmission of 2009 pandemic influenza A (H1N1) virus among an urban and rural population in Kenya, 2009-2010. Plos One 7(6): E38166, 2012

Procalcitonin for diagnosis of bacterial pneumonia in critically ill patients during 2009 H1N1 influenza pandemic: a prospective cohort study, systematic review and individual patient data meta-analysis. Critical Care 18(2): R44, 2014

Household transmission of pneumococcal pneumonia associated with pandemic influenza (H1N1) 2009. Nihon Kokyuki Gakkai Zasshi 48(4): 322-327, 2010

Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States. New England Journal of Medicine 361(27): 2619-2627, 2009

Influenza virus contamination of common household surfaces during the 2009 influenza A (H1N1) pandemic in Bangkok, Thailand: implications for contact transmission. Clinical Infectious Diseases 51(9): 1053-1061, 2010