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Hypertriglyceridemic waist phenotype and chronic kidney disease in a Chinese population aged 40 years and older

Li, Y.; Zhou, C.; Shao, X.; Liu, X.; Guo, J.; Zhang, Y.; Wang, H.; Wang, X.; Li, B.; Deng, K.; Liu, Q.; Holthöfer, H.; Zou, H.

Plos one 9(3): E92322

2014


ISSN/ISBN: 1932-6203
PMID: 24663403
DOI: 10.1371/journal.pone.0092322
Accession: 053633573

To examine the relationship between the HW phenotype and risk for CKD in a community population aged 40 years and older. A cross-sectional study was conducted in Zhuhai from June to October 2012. The participants were divided into three groups: Group 1, Waist circumference >90 cm in men or >85 cm in women and triglycerides ≥2 mmol/l; Group 3, Waist circumference ≤90 cm in men or ≤85 cm in women and triglycerides <2 mmol/l; Group 2, The remaining participants. The prevalence of the three subgroups and CKD were determined. The association between HW phenotype and CKD was then analyzed using SPSS (version 13.0). After adjusting for age and sex, Group 1 was associated with CKD (OR 3.08, 95% CI 2.01, 4.73, P<0.001), when compared with Group 3. Further adjustment for factors which were potential confounders and unlikely to be in the causal pathway between the HW phenotype and CKD, Group 1 was still significantly associated with CKD. The OR for CKD was 2.65 (95% CI 1.65, 4.26, P<0.001). When adjusted for diabetes and hypertension, the association of Group 1 and CKD was still significant (OR 2.09, 95% CI 1.26, 3.45, P = 0.004). Group 2 was associated with CKD (OR 1.81, 95% CI 1.29, 2.53, P = 0.001), when compared with Group 3. Further adjustment for factors which were potential confounders, Group 2 was still significantly associated with CKD. The OR for CKD was 1.75 (95% CI 1.22, 2.51, P = 0.002). When adjusted for diabetes and hypertension, the association between Group 2 and CKD still existed. The OR for CKD was 1.48 (95% CI 1.01, 2.16, P = 0.046). Our results showed that HW phenotype was associated with CKD in the population aged 40 years and older.

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