+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Immune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice

Immune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice

Plos one 8(3): E59995

ISSN/ISBN: 1932-6203

PMID: 23555858

DOI: 10.1371/journal.pone.0059995

Few experimental models are available for the study of natural resistance to cancer. One of them is the SR/CR (spontaneous regression/complete resistance) mouse model in which natural resistance to a variety of cancer types appeared to be inherited in SR/CR strains of BALB/c and C57BL/6 mice. The genetic, cellular, and molecular effector mechanisms in this model are largely unknown, but cells from the innate immune system may play a significant role. In contrast to previous observations, the cancer resistance was limited to S180 sarcoma cancer cells. We were unable to confirm previous observations of resistance to EL-4 lymphoma cells and J774A.1 monocyte-macrophage cancer cells. The cancer resistance against S180 sarcoma cells could be transferred to susceptible non-resistant BALB/c mice as well as C57BL/6 mice after depletion of both CD4+/CD8+ leukocytes and B-cells from SR/CR mice. In the responding recipient mice, the cancer disappeared gradually following infiltration of a large number of polymorphonuclear granulocytes and remarkably few lymphocytes in the remaining tumor tissues. This study confirmed that the in vivo growth and spread of cancer cells depend on a complex interplay between the cancer cells and the host organism. Here, hereditary components of the immune system, most likely the innate part, played a crucial role in this interplay and lead to resistance to a single experimental cancer type. The fact that leukocytes depleted of both CD4+/CD8+ and B cells from the cancer resistant donor mice could be transferred to inhibit S180 cancer cell growth in susceptible recipient mice support the vision of an efficient and adverse event free immunotherapy in future selected cancer types.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053696371

Download citation: RISBibTeXText

Related references

Enhanced sensitivity of DEAE-dextran treated spleen cells from normal BALB/C mice, B-lymphocyte depleted BALB/C mice and nude mice to in vitro antibody-complement mediated immune cytolysis. Medical Microbiology and Immunology 160(4): 251-256, 1974

Interferon-b gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 95(24): 411-16, 1998

Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 95(24): 14411-14416, 1998

Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice. Cancer Research 73(11): 3371-3380, 2013

A modified method to induce immune polyclonal ascites fluid in BALB/c mice using Sp2/0-Ag14 cells. Journal of Immunological Methods 87(2): 169-177, 1986

In vitro differentiation of T-cells capable of mediating the regression of established syngeneic tumors in mice. Cancer Research 47(5): 1354-1360, 1987

Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice. Cancer Research 58(23): 5432-5438, 1998

Stimulation of lymphoid cells from normal and immune mice by syngeneic BALB/c plasma cell tumors. Journal of Immunology 116(1): 202-209, 1976

Treatment of established intrahepatic syngeneic colorectal tumors by retroviral HS-Tk gene transfer in BALB/c mice. Journal of Cellular Biochemistry Suppl 1995(21A): 425, 1995

Regulation of immune responses against the syngeneic ADJ-PC-5 plasmacytoma in BALB/c mice. II. Suppression of T-cell cytotoxicity by pretreatment of mice with subimmunogenic doses of tumour cells. Immunology 43(1): 145-152, 1981

Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene. Cancer Research 57(14): 2832-2834, 1997

The in vitro activity of peritoneal exudate cells of NZB-B1 and BALB-C mice following intraperitoneal injection of spleen cells from diseased and "healthy" NZB-B1 and from old and young BALB-C mice. British Journal of Experimental Pathology 54(2): 123-134, 1973

Bovine herpesvirus-1 recombinant expressing PrV gB and gC induce type 1 predominant immune response in BALB/c mice. Antiviral Research 53(3): A58, 2002

The hair dyes PPD and PTD fail to induce a T(H)2 immune response following repeated topical application in BALB/c mice. Journal of immunotoxicology 8(1): 46-55, 2011

Mammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice. Scientific Reports 7(1): 8152, 2017