+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Immunohistochemical expression and significance of NM23 suppressor protein in primary gastric adenocarcinoma

Immunohistochemical expression and significance of NM23 suppressor protein in primary gastric adenocarcinoma

Bosnian Journal of Basic Medical Sciences 13(2): 72-77

NM 23 protein was originally identified as a metastasis suppressor protein. The expression of NM23 has been correlated with tumour metastatic potential in various human carcinoma, mostly in ductal breast and colorectal carcinomas. Evidence for their expression in gastric cancer is rather contradictory, both for protein expression status and prognostic value. This study was done to analyze the immunohistochemical expression of NM23 in gastric carcinoma, and correlation of the degree of staining with clinicopathological parameters was investigated. In a retrospective immunohistochemical study specimens obtained from 56 gastric cancer patients who had undergone gastrectomy with perigastric lymphadenectomy were analysed, in correlation with classical clinical-pathological parameters of tumours, WHO-, Lauren-, Goseki-, and Ming- classification. NM 23 gene expression was compared in gastric adenocarcinoma and tumour-adjacent non-neoplastic gastric mucosa. A semiquantitative immunostaining evaluation (score 0-3) was used, counting the percentage of stained cells. Statistical analysis was performed using Kolmogorov-Smirnov test, and Spearman rank correlation test. The investigated group consisted of 40 males and 16 females (2.5:1) with a mean age of 63 years (range: 48-81 years). The percentage of positive expression of NM23 (score 3) were in 30 (53.5%) specimens in non-neoplastic mucosa in adjacent gastric carcinoma, and negative (score 0-2) in all 56 (100%) specimens of gastric adenocarcinoma. NM23 expression was higher in non-neoplastic mucosa than in adjacent gastric adenocarcinoma tissue (p<0.0001). NM23 protein expression did not correlate with gender (p=0.115), tumour size (p=0.844), tumour grade (p=0.172), lymphovascular invasion (p=0.606), lymph node metastases (p=0.311), Lauren classification (p=0.426), Goseki classification (p=0.458) and Ming classification (p=0.212). Our series did not show a significant correlation between NM23 expression and analysed clinico-pathological variables, but these results suggest that protein NM23 may have a role in gastric carcinoma pathogenesis.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 053702797

Download citation: RISBibTeXText

PMID: 23725501

Related references

The immunohistochemical study of the expression of nm23 gene protein and P-glycoprotein expression on stomach adenocarcinoma. Chung-Ang Journal of Medicine 21(1): 13-24, 1996

P53, c-erbB-2 and nm23 expression have no prognostic significance in primary pulmonary adenocarcinoma. European Journal of Cardio-Thoracic Surgery 11(5): 838-842, 1997

Prognostic significance of nm23-protein expression in malignant melanoma An immunohistochemical study. Pigment Cell Research 0(Suppl. 5): 47, 1996

Evaluation of the prognostic significance of nm23/NDP kinase protein expression in cervical carcinoma: an immunohistochemical study. Gynecologic Oncology 61(3): 378-383, 1996

Clinical significance of nm23 expression and chromosome 17 numerical aberrations in primary gastric cancer. Medical Oncology 19(4): 239-248, 2002

The significance of nm23 protein expression in human gastric carcinomas. Surgery Today 26(12): 957-965, 1996

Expression of the nm23 homologues nm23-H4, nm23-H6, and nm23-H7 in human gastric and colon cancer. Journal of Pathology 205(5): 623-632, 2005

The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma. British Journal of Cancer 69(5): 943-946, 1994

Immunohistochemical analysis of nm23 gene product/NDP kinase expression in pulmonary adenocarcinoma: lack of prognostic value. British Journal of Cancer 66(3): 533-536, 1992

Nm23 gene expression in gastric carcinoma: an immunohistochemical study. Australian and new Zealand Journal of Surgery 68(3): 180-182, 1998

Expression of nm23 and KAI1 and their clinical significance in gallbladder adenocarcinoma. Zhonghua Zhong Liu Za Zhi 30(6): 441-443, 2008

Multivariate analysis of immunohistochemical evaluation of protein expression in pancreatic ductal adenocarcinoma reveals prognostic significance for persistent Smad4 expression only. Cellular Oncology 35(2): 119-126, 2012

Immunohistochemical analysis of c-erbB-2 and nm23 expression in early gastric carcinoma. Japanese Journal of Gastroenterology 93(9): 613-619, 1996

Expression of human nm23-H1-metastasis suppressor gene in hepatocellular carcinoma and its clinical significance. Zhongguo Zhongliu Linchuang 25(5): 346-348, 1998