+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Immunomorphological assessment of regional lymph nodes for predicting metastases in oral squamous cell carcinoma



Immunomorphological assessment of regional lymph nodes for predicting metastases in oral squamous cell carcinoma



Indian Journal of Dental Research 23(1): 121-122



Oral squamous cell carcinoma is the most common neoplasm and comprises of approximately 80% of the cancers occurring in the oral cavity. The role of the host response to this neoplasm has been recognized, and for many years the regional lymph node in tumor-bearing hosts has been considered as an anatomic barrier to the systematic dissemination of tumor cells. Morphological evaluation of the regional nodes has aided in understanding the immune response. The current study was carried out to observe the morphological changes occurring in the regional lymph nodes and to evaluate whether these features could be helpful in assessing the immunological status of the patient, and thereby, the prognosis of the patient. The study was based on lymph nodes from 63 patients with oral squamous cell carcinoma, who underwent radical neck dissection or modified neck dissection. In the lymph node, four morphological patterns were observed that included lymphocyte predominance, germinal center predominance, mixed pattern (sinus Histiocytosis), and an unstimulated pattern. The cases were then divided into four groups according to the predominant immunoreactivity pattern based on the World Health Organization (WHO) standardized system for reporting human lymph node morphology. Revealed that risk of metastases to cervical lymph nodes in patients with lymphocyte predominance was less (28.6%) when compared to the high risk of metastases with germinal center predominance (68%), and these results were statistically significant (P < 0.05). Patients with a mixed pattern showed less risk of metastases (45.4%), while those with an unstimulated pattern had increased risk of metastases (66.6%), but the results were not statistically significant. It was also found that in the positive nodes, germinal center hyperplasia (50.2%) was the predominant pattern. The present study revealed that patients with lymphocyte predominance had less risk of metastases and patients with germinal center predominance had a high risk of metastases to the lymph node.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 053706298

Download citation: RISBibTeXText

PMID: 22842267


Related references

Immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma. Journal of Oral and Maxillofacial Pathology 18(3): 349-355, 2015

Galectin 3 expression in regional lymph nodes and lymph node metastases of oral squamous cell carcinomas. Bmc Cancer 18(1): 823, 2018

Metastases to supramandibular facial lymph nodes in patients with squamous cell carcinoma of the oral cavity. Journal of Oral and Maxillofacial Surgery 67(7): 1401-1408, 2009

WEEKLY clinicopathological exercises: squamous-cell carcinoma, Grade III, of the lung, with metastases to regional lymph nodes and pleura. New England Journal of Medicine 244(7): 264-267, 1951

The role of Bak expression in apoptosis of the oral squamous cell carcinoma (OSCC) and metastases to lymph nodes (LNMs). Roczniki Akademii Medycznej W Bialymstoku 49 Suppl 1: 14-15, 2005

WEEKLY clinicopathological exercises: squamous-cell carcinoma of the lung, with metastases to the regional lymph nodes, pleura, ribs and clavicle; hydrothorax. New England Journal of Medicine 244(10): 371-375, 1951

The prevalence of occult metastases in nonsentinel lymph nodes after step-serial sectioning and immunohistochemistry in cN0 oral squamous cell carcinoma. Laryngoscope 121(2): 294-298, 2011

Oral squamous cell carcinoma with multiple neck metastases--cases with more than ten pathologically positive lymph nodes in the unilateral side. Journal of Oral and Maxillofacial Surgery 71(4): 793-797, 2013

Lymph nodes of patients with regional metastases from head and neck squamous cell carcinoma as a predictor of pathologic outcome: size changes at CT before and after radiation therapy. Ajnr. American Journal of Neuroradiology 23(10): 1627-1631, 2002

Distribution of metastatic regional lymph nodes in squamous cell carcinoma of the oral commissure and its implications for treatment in the neck. British Journal of Oral and Maxillofacial Surgery 56(9): 898-900, 2018

Evaluation of clinical and histomorphological parameters as potential predictors of occult metastases in sentinel lymph nodes of early squamous cell carcinoma of the oral cavity. Annals of Surgical Oncology 17(2): 527-535, 2010

Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in primary oral squamous cell carcinoma and corresponding metastases in cervical lymph nodes: association with the metastasis suppressor CD82. Anticancer Research 31(10): 3521-3526, 2011

Effects of postoperative chemotherapy and radiotherapy on patients with squamous cell carcinoma of the oral cavity and multiple regional lymph node metastases. International Journal of Oral and Maxillofacial Surgery 43(6): 680-685, 2015

Correlating the depth of invasion at specific anatomic locations with the risk for regional metastatic disease to lymph nodes in the neck for oral squamous cell carcinoma. Head and Neck 39(5): 974-979, 2017

Cervical lymph nodes with or without metastases from oral squamous carcinoma: a correlation of MRI findings and histopathologic architecture. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 109(6): 890-899, 2010