+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Improvement of type 2 diabetes mellitus in obese and non-obese patients after the duodenal switch operation



Improvement of type 2 diabetes mellitus in obese and non-obese patients after the duodenal switch operation



Journal of Obesity 2011: 860169



Introduction. Type 2 diabetes mellitus (T2DM) is one of the most important obesity-related comorbidities. This study was undertaken to characterise the effect of the biliopancreatic diversion with duodenal switch (BPD-DS) in morbidly obese and nonmorbidly obese diabetic patients. Methods. Outcome of 74 obese diabetic patients after BPD-DS and 16 non-obese diabetic patients after BPD or gastric bypass surgery was evaluated. Insulin usage, HbA(1c)-levels, and index of HOMA-IR (homeostasis model assessment of insulin resistence) were measured. Results. A substantial fraction of patients is free of insulin and shows an improved insulin sensitivity early after the operation, another fraction gets free of insulin in a 12-month period after the operation and a small fraction of long-term insulin users will not get free of insulin but nevertheless shows an improved metabolic status (less insulin needed, normal HbA(1c)-levels). Conclusion. BPD-DS leads to an improvement of T2DM in obese and non-obese patients. Nevertheless, more data is needed to clarify indications and mechanisms of action and to adjust our operation techniques to the needs of non-obese diabetic patients.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053750216

Download citation: RISBibTeXText

PMID: 21461399

DOI: 10.1155/2011/860169


Related references

Laparoscopic sleeve gastrectomy with ileal interposition (SGIT): a modified duodenal switch for resolution of type 2 diabetes mellitus in lesser obese patients (BMI < 35). World Journal of Surgery 35(1): 109-110, 2011

Endocrine effects of duodenal-jejunal exclusion in obese patients with type 2 diabetes mellitus. Journal of Endocrinology 231(1): 11-22, 2017

Population pharmacokinetics of metformin in obese and non-obese patients with type 2 diabetes mellitus. European Journal of Clinical Pharmacology 68(6): 961-968, 2012

The prevalence of metabolic syndrome in obese and non-obese patients with newly-diagnosed type 2 diabetes mellitus. International Journal of Obesity 24(Supplement 1): S80, 2000

Duodenal-jejunal bypass liner to treat type 2 diabetes mellitus in morbidly obese patients. Current Cardiology Reports 16(3): 454, 2014

Is There a Role for Visceral Adiposity in Inducing Type 2 Diabetes Remission in Severely Obese Patients Following Biliopancreatic Diversion with Duodenal Switch Surgery?. Obesity Surgery 26(8): 1717-1727, 2018

Large granular lymphocytes numbers in obese and non-obese patients with newly-diagnosed type 2 diabetes mellitus. International Journal of Obesity 24(Supplement 1): S146, 2000

The effects of adiponectin and inflammatory cytokines on diabetic vascular complications in obese and non-obese patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice 111: 58-65, 2016

Correlation between weight loss and improvement of diabetes mellitus among obese type 2 diabetic patients. Diabetology International 4(2): 132-137, 2013

Comparative efficacy and safety of the duodenal-jejunal bypass liner in obese patients with type 2 diabetes mellitus: A case control study. Diabetes, Obesity and Metabolism 20(8): 1868-1877, 2018

Impact of sleeve gastrectomy with ileal interposition duodenojejunal bypass operation on lipid metabolism in non-obese type 2 diabetes mellitus patients. Zhonghua Wei Chang Wai Ke Za Zhi 16(3): 273-275, 2014

Laparoscopic Biliopancreatic Diversion with Duodenal Switch - The Most Effective Operation for Type 2 Diabetes Mellitus. How I do it?. Chirurgia 113(5): 704-711, 2018

Plasma total homocysteine concentrations in obese and non-obese female patients with type 2 diabetes mellitus; its relations with plasma oxidative stress and nitric oxide levels. Clinical Hemorheology and Microcirculation 33(1): 41-46, 2005

Different etiologies of type 2 non insulin dependent diabetes mellitus in obese and non obese subjects. Diabetologia 34(7): 483-487, 1991

Serum fetuin-A levels in obese and non-obese subjects with and without type 2 diabetes mellitus. Clinica Chimica Acta; International Journal of Clinical Chemistry 476: 98-102, 2017