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In vitro activity of ceftazidime-NXL104 against 396 strains of beta-lactamase-producing anaerobes



In vitro activity of ceftazidime-NXL104 against 396 strains of beta-lactamase-producing anaerobes



Antimicrobial Agents and ChemoTherapy 55(7): 3616-3620



NXL14, a novel β-lactamase inhibitor, was tested at a constant concentration of 4 µg/ml in combination with ceftazidime (CAZ), with and without added metronidazole, against 396 β-lactamase-producing strains of anaerobic bacteria. MIC5/MIC9 values for Bacteroides fragilis and the B. fragilis group were 8/16 and 64/>128 µg/ml, respectively. Although CAZ-NXL14 had limited activity against most anaerobic strains, in combination with metronidazole it shows potential for treating mixed infections involving resistant Enterobacteriaceae and anaerobes.

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Accession: 053768891

Download citation: RISBibTeXText

PMID: 21537015

DOI: 10.1128/AAC.01682-10


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