+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

In vitro susceptibility patterns of Aspergillus and Fusarium species isolated from equine ulcerative keratomycosis cases in the midwestern and southern United States with inclusion of the new antifungal agent voriconazole

In vitro susceptibility patterns of Aspergillus and Fusarium species isolated from equine ulcerative keratomycosis cases in the midwestern and southern United States with inclusion of the new antifungal agent voriconazole

Veterinary Ophthalmology 12(5): 318-324

To evaluate and compare the in vitro susceptibility of Aspergillus and Fusarium spp. isolated from horses with ulcerative keratomycosis, address regional differences in equine keratomycosis isolates, and provide susceptibility data to update prior studies. Fourteen horses with ulcerative keratomycosis. Banked fungal isolates from equine corneal ulcers (eight Aspergillus spp. and six Fusarium spp.) were identified at The University of Texas Health Science Center at San Antonio. In vitro minimum inhibitory concentration and susceptibility to natamycin, fluconazole, itraconazole, voriconazole, ketoconazole, and miconazole were determined for each isolate. Fungi were significantly more susceptible to voriconazole than to natamycin, itraconazole, fluconazole, and ketoconazole, but miconazole susceptibility did not differ significantly from voriconazole. Aspergillus spp. were most susceptible to voriconazole, miconazole, and itraconazole, which were significantly better to fluconazole and ketoconazole. Fusarium spp. susceptibility was greatest to natamycin and voriconazole and lowest to itraconazole and ketoconazole. Fusarium spp. were significantly less susceptible to itraconazole and ketoconazole compared to natamycin. No significant differences in susceptibility were found when isolates from Florida were compared with isolates from other states. Based on in vitro evidence, voriconazole appears to be the most effective antifungal for initial treatment of equine keratomycosis in the midwestern and southern United States. Results are comparable with previous studies in that isolated fungi from equine keratomycosis cases showed consistently poor susceptibility to fluconazole. Organisms isolated in different geographic locations of the midwestern and southern United States appeared to have similar patterns of antifungal susceptibility.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053776995

Download citation: RISBibTeXText

PMID: 19751493

DOI: 10.1111/j.1463-5224.2009.00721.x

Related references

In vitro susceptibility patterns of fungi associated with keratomycosis in horses of the northeastern United States: 68 cases (1987-2006). Journal of the American Veterinary Medical Association 231(7): 1086-1091, 2007

In vitro evaluation of combination antifungal activity against Fusarium species isolated from ocular tissues of keratomycosis patients. American Journal of Ophthalmology 146(5): 724-728, 2008

Keratomycosis caused by Aspergillus viridinutans: an Aspergillus fumigatus-resembling mold presenting distinct clinical and antifungal susceptibility patterns. Medical Mycology 50(5): 525-528, 2012

In vitro resistance of clinical Fusarium species to amphotericin B and voriconazole using the EUCAST antifungal susceptibility method. Diagnostic Microbiology and Infectious Disease 85(4): 438-443, 2016

In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species. Antimicrobial Agents and ChemoTherapy 52(4): 1396-1400, 2008

Sporulation of Fusarium solani f. sp. glycines, Causal Agent of Sudden Death Syndrome, on Soybeans in the Midwestern and Southern United States. Plant Disease 81(6): 566-569, 1997

Antimicrobial susceptibility patterns of fungi isolated from horses with ulcerative keratomycosis. American Journal of Veterinary Research 59(2): 138-142, 1998

Evaluation of antimicrobial susceptibility patterns in Campylobacter spp isolated from dairy cattle and farms managed organically and conventionally in the midwestern and northeastern United States. Journal of the American Veterinary Medical Association 228(7): 1074-1081, 2006

Species distribution and in vitro antifungal susceptibility patterns of 75 clinical isolates of Fusarium spp. from northern Italy. Antimicrobial Agents and ChemoTherapy 52(7): 2683-2685, 2008

Prevalence and in vitro antifungal susceptibility of cryptic species of the genus Aspergillus isolated in clinical samples. Enfermedades Infecciosas Y Microbiologia Clinica 37(5): 296-300, 2019

In vitro susceptibility of Aspergillus clinical isolates to amphotericin B , itraconazole and voriconazole by E-test and the effect of prior antifungal exposure. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 43: 472, 2003

In vitro susceptibility testing of Candida and Aspergillus spp. to voriconazole and other antifungal agents using Etest: results of a French multicentre study. International Journal of Antimicrobial Agents 25(4): 321-328, 2005

Microdilution susceptibility testing of amphotericin B, itraconazole, and voriconazole against clinical isolates of Aspergillus and Fusarium species. Journal of Clinical Microbiology 37(12): 3946-3951, 1999

Species identification and in vitro antifungal susceptibility testing of Aspergillus section Nigri strains isolated from otomycosis patients. Journal de Mycologie Medicale 28(2): 279-284, 2018

Time-Kill Kinetics and In Vitro Antifungal Susceptibility of Non-fumigatus Aspergillus Species Isolated from Patients with Ocular Mycoses. Mycopathologia 181(3-4): 225-233, 2016