+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Incidence, trends, and predictors of ischemic stroke 1 year after an acute myocardial infarction

Incidence, trends, and predictors of ischemic stroke 1 year after an acute myocardial infarction

Stroke 45(11): 3263-3268

Ischemic stroke after acute myocardial infarction is an important complication. It is unknown whether the risk has changed because the treatment of acute myocardial infarction has improved during the past decade. There is also conflicting data about predictors of stroke risk. To obtain the 1-year incidence of stroke after acute myocardial infarction, the Register of Information and Knowledge about Swedish Heart Intensive Care Admissions database for the years 1998 to 2008 was merged with the Swedish National Patient Register (NPR). The time trend was studied by dividing the entire time period into 5 separate periods. Independent predictors were identified using a multivariable Cox proportional hazards regression model. Between 1998 and 2008, 7185 of 173 233 patients with acute myocardial infarction had an ischemic stroke within 1 year (4.1%). There was a 20% relative risk reduction during the study period (1998-2000 versus 2007-2008) relative risk 0.80 (95% confidence interval, 0.75-0.86; P<0.001. Independent predictors of stroke were age, female sex, ST-segment-elevation myocardial infarction, previous stroke, previous diabetes mellitus, heart failure at admission, angiotensin-converting enzyme inhibitor treatment and atrial fibrillation. Reperfusion treatment with fibrinolysis and percutaneous coronary intervention and treatment with aspirin, P2Y12-inhibitors, and statins predicted a reduced risk of stroke. The risk of ischemic stroke within a year after myocardial infarction is substantial but has clearly been reduced during the studied time period. The major predictive factors found to correlate well with previous investigations. Reperfusion treatment, thrombocyte aggregation inhibition, and lipid lowering are the main contributors to the observed risk reduction.

(PDF emailed within 0-6 h: $19.90)

Accession: 053793185

Download citation: RISBibTeXText

PMID: 25236874

DOI: 10.1161/STROKEAHA.114.005770

Related references

Incidence, trends, and predictors of ischemic stroke 30 days after an acute myocardial infarction. Stroke 45(5): 1324-1330, 2014

Mortality after ischemic stroke in patients with acute myocardial infarction: predictors and trends over time in Sweden. Stroke 44(11): 3050-3055, 2013

Hemorrhagic stroke the first 30 days after an acute myocardial infarction: incidence, time trends and predictors of risk. International Journal of Cardiology 176(1): 133-138, 2015

Trends in the incidence of acute myocardial infarction and stroke: a 21-year follow-up of the Oslo study. Scandinavian Cardiovascular Journal 38(4): 216-221, 2004

Recurrent Stroke, Myocardial Infarction, and Major Vascular Events during the First Year after Acute Ischemic Stroke: The Multicenter Prospective Observational Study about Recurrence and Its Determinants after Acute Ischemic Stroke I. Journal of Stroke and Cerebrovascular Diseases 25(3): 656-664, 2016

Twenty-year trends in the incidence of stroke complicating acute myocardial infarction: Worcester Heart Attack Study. Archives of Internal Medicine 168(19): 2104-2110, 2008

Twenty-five year (1986-2011) trends in the incidence and death rates of stroke complicating acute myocardial infarction. American Journal of Medicine: -, 2018

40-year seasonality trends in occurrence of myocardial infarction, ischemic stroke, and hemorrhagic stroke. Epidemiology: -, 2018

One-Year Incidence, Time Trends, and Predictors of Recurrent Ischemic Stroke in Sweden From 1998 to 2010: An Observational Study. Stroke 48(8): 2046-2051, 2017

Temporal trends in incidence of myocardial infarction and ischemic stroke by socioeconomic position in Sweden 1987-2010. Plos One 9(8): E105279-E105279, 2015

Changing Trends of Atherosclerotic Risk Factors Among Patients With Acute Myocardial Infarction and Acute Ischemic Stroke. American Journal of Cardiology 119(10): 1532-1541, 2017

Depression and Anxiety Screens as Predictors of 8-Year Incidence of Myocardial Infarction and Stroke in Primary Care Patients. Psychosomatic Medicine 78(5): 593-601, 2017

Incidence and Outcomes of Myocardial Infarction in Patients Admitted With Acute Ischemic Stroke. Stroke 48(11): 2931-2938, 2017

Trends in the incidence and outcomes of in-hospital stroke complicating acute myocardial infarction. American Journal of Cardiology 92(4): 383-388, August 15, 2003

Early stroke following acute myocardial infarction: incidence, predictors and outcome in six Middle-Eastern countries. Cerebrovascular Diseases 32(5): 471-482, 2012