+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Increased serum leucine, leucine-37 levels in psoriasis: positive and negative feedback loops of leucine, leucine-37 and pro- or anti-inflammatory cytokines



Increased serum leucine, leucine-37 levels in psoriasis: positive and negative feedback loops of leucine, leucine-37 and pro- or anti-inflammatory cytokines



Human Immunology 71(12): 1161-1171



Expression of leucine, leucine-37 (LL-37) is enhanced in keratinocytes of skin lesions with psoriasis. We examined serum LL-37 levels in patients with psoriasis vulgaris. Serum LL-37 levels in patients were higher than in normal controls, and were reduced after cyclosporine A treatment. In both groups, LL-37 and interleukin (IL)-17 levels inversely correlated. In patients, LL-37 levels correlated with interferon (IFN)-γ and IL-10 levels. In controls, LL-37 levels inversely correlated with tumor necrosis factor (TNF)-α, IL-6, IL-1β, and IL-22 levels. IFN-γ, IL-17, IL-22, TNF-α, IL-6, and IL-1β enhanced, and IL-10, IL-4, IL-13, and cyclosporine A suppressed, LL-37 secretion from keratinocytes and neutrophils. LL-37 enhanced IFN-γ, IL-4, IL-13, and TNF-α secretion from CD3/CD28-stimulated T cells, suppressed TNF-α, IL-1β, IL-6, and IL-10 secretion from lipopolysaccharide-stimulated monocytes, and IL-17, IL-22, IL-1β, IL-6, and IL-10 secretion from CD3/CD28-stimulated T cells. LL-37 may sustain its production by enhancing IFN-γ or reducing IL-10 production, while suppressing its production by reducing IL-17, IL-22, TNF-α, IL-1β, or IL-6 and enhancing IL-4 or IL-13 production. In patients, systemic LL-37 production is enhanced, and an IFN-γ/LL-37-positive feedback loop may exist. In controls, negative feedback by LL-37 on TNF-α, IL-1β, IL-22, and IL-6 may exist. In both groups, negative feedback by LL-37 on IL-17 may exist. LL-37 may act as an effector and regulator.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053806288

Download citation: RISBibTeXText

PMID: 20849904

DOI: 10.1016/j.humimm.2010.09.005


Related references

Pathway for iso leucine formation from pyruvate by leucine biosynthetic enzymes in leucine accumulating iso leucine revertants of serratia marcescens. Journal of Biochemistry 82(1): 95-104, 1977

Semi synthesis and biological properties of the b 24 leucine b 25 leucine and b 24 leucine b 25 leucine analogs of human insulin. Experientia 37(8): 811-813, 1981

Semisynthesis and biological properties of the [B24-leucine]-, [B25-leucine[- and [B24-leucine, B25-leucine]-analogues of human insulin. Experientia 37(8): 811-813, 1981

CXCR2 carboxyl-terminus leucine-leucine and isoleucine-leucine motifs are involved in receptor internalization and chemotaxis. Cytokine 11(11): 943, 1999

Leucine clamp a new method to assess tissue sensitivity and specificity to leucine and its disposal independent of changes in leucine concentration. Surgical Forum (Chicago) 37: 39-41, 1986

Surface properties of aqueous amino acid solutions II. Leucine-leucine hydrochloride and leucine-sodium leucinate mixtures. Journal of Colloid and Interface Science 288(2): 402-406, 2005

24H kinetics of leucine oxidation in subjects receiving either -leucine as free amino acid or as intrinsically labeled leucine-casein. FASEB Journal 16(5): A745-A746, 2002

Relationship of plasma leucine and alpha-ketoisocaproate during a L-[1-13C]leucine infusion in man: a method for measuring human intracellular leucine tracer enrichment. Metabolism: Clinical and Experimental 31(11): 1105-1112, 1982

Leucine kinetics in man quantitative fate of dietary leucine and assessment of leucine requirements. American Journal of Clinical Nutrition 45(4): 875, 1987

Comparative utilization of l leucine d leucine and dl alpha hydroxy leucine by the chick. Nutrition Reports International 16(5): 611-616, 1977

A comparative study on the pancreatic uptake of d leucine dl leucine and l leucine with l methionine. Science Reports of the Research Institutes Tohoku University Series C Medicine 26(1-2): 36-38, 1979

Relationship of plasma leucine and alpha keto iso caproate during a l 1 carbon 13 labeled leucine infusion in man a method for measuring human intra cellular leucine tracer enrichment. Metabolism Clinical & Experimental 31(11): 1105-1112, 1982

Mechanism of feedback inhibition by leucine. Binding of leucine to wild-type and feedback resistant -isopropylmalate syntheses and its structural consequences. Biochemistry 12(16): 2980-2986, 1973

Mechanism of feedback inhibition by leucine. Binding of leucine to wild-type and feedback-resistant alpha-isopropylmalate synthases and its structural consequences. Biochemistry 12(16): 2980-2986, 1973

Cyclic peptides. XIV. Syntheses of [4-l-leucine]-, [4-D-leucine]-, and [3-L-proline, 4-D-leucine]-Cyl-2. International Journal of Peptide and Protein Research 20(3): 246-253, 1982