+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Induction of oral immune tolerance in systemic lupus erythematosus-like murine model by recombinant nucleosomal universal Th cell epitope



Induction of oral immune tolerance in systemic lupus erythematosus-like murine model by recombinant nucleosomal universal Th cell epitope



Zhonghua Yi Xue Za Zhi 89(24): 1702-1706



To explore the feasibility of oral immune tolerance of systemic lupus erythematosus (SLE)-like model induced by nucleosomal Th cell epitope via the attenuated Salmonella typhimurium. SLE-like murine model was established by immunization with apoptotic syngeneic lymphocytes. The recombinant strains were orally administrated to induce immune tolerance. The levels of serum autoantibodies, such as anti-ANA, ds-DNA, and antinucleosome antibody, leukopenia, proteinuria and kidney injuries were evaluated. SLE-like murine model was successfully established. Compared with controls, it was shown that CTLA4-Ig-H2B group could dramatically reduce the levels of serum autoantibodies, such as anti-ANA, ds-DNA and antinucleosome antibody and ameliorate leukopenia and proteinuria (all P < 0.05). Immune complex deposits of IgG in glomeruli were lower in CTLA4-Ig-H2B (1.35 +/- 0.16) than in CTLA4-Ig (1.66 +/- 0.23) and H2B (1.69 +/- 0.24) (both P < 0.05). The score of glomeruli lesion of CTLA4-Ig-H2B (1.26 +/- 0.14) was significantly lower than those of CTLA4-Ig (1.73 +/- 0.25) and H2B (1.71 +/- 0.20) (both P < 0.05). Combined with CTLA4-Ig, it is feasible to induce oral immune tolerance of SLE models with nucleosomal Th cell epitope via the attenuated Salmonella typhimurium. This may provide a novel way to prevent and treat SLE by oral immune tolerance.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 053822528

Download citation: RISBibTeXText

PMID: 19957531


Related references

T-cell tolerance induction is normal in the (NZB x NZW)F1 murine model of systemic lupus erythematosus. Immunology 99(3): 345-351, 2000

Breakdown of mucosal immunity in the gut and resultant systemic sensitization by oral antigens in a murine model for systemic lupus erythematosus. Journal of Immunology 174(9): 5499-5506, 2005

Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus. Arthritis and Rheumatism 52(6): 1684-1693, 2005

Interleukin-6 promotes systemic lupus erythematosus progression with Treg suppression approach in a murine systemic lupus erythematosus model. Clinical Rheumatology 33(11): 1585-1593, 2014

Induction of systemic lupus erythematosus like disease by abnormal t cell b cell cooperation in genetically nonautoimmune mice preferential formation of auto antibodies characteristic of systemic lupus erythematosus. Immunobiology 160(1): 24, 1981

Failure of oral atorvastatin to modulate a murine model of systemic lupus erythematosus. Arthritis and Rheumatism 58(7): 2098-2104, 2008

Dietary vitamin a deficiency and the immune system in a murine model of systemic lupus erythematosus. Nutrition Research 16(2): 279-292, 1996

Hyperexpression of cyclooxygenase 2 in the lupus immune system and effect of cyclooxygenase 2 inhibitor diet therapy in a murine model of systemic lupus erythematosus. Arthritis and Rheumatism 56(12): 4132-4141, 2007

Pregnancy Associated with Systemic Lupus Erythematosus: Immune Tolerance in Pregnancy and Its Deficiency in Systemic Lupus Erythematosus--An Immunological Dilemma. Journal of Immunology Research 2015: 241547, 2015

Progressive systemic sclerosis and localized scleroderma morphea with positive lupus erythematosus cell test and unusual systemic manifestations compatible with systemic lupus erythematosus presentation of 14 cases including 1 set of identical twins 1 with scleroderma and the other with systemic lupus erythematosus review of the literature. Medicine (Baltimore) 50(3): 199-222, 1971

Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus. Journal of Experimental Medicine 181(3): 1157-1167, 1995

Characterization of IdLNF1-specific T cell clones from the (NZB x SWR)F1 murine model for systemic lupus erythematosus. Clinical Immunology and Immunopathology 68(3): 273-282, 1993

Liver-associated lymphocytes expressing NK1.1 are essential for oral immune tolerance induction in a murine model. Hepatology 29(3): 746-755, 1999

Deficiency of immunologic tolerance in murine systemic lupus erythematosus. Anon Abstracta Xii Congressus Rheumatologicus Internationalis Praga (Abstracts 12th International Rheumatological Congress ) Np J R Geigy S A : basle, Switz 642, 1969

Abnormal responses to ingested substances in murine systemic lupus erythematosus: apparent effect of a casein-free diet on the development of systemic lupus erythematosus in NZB/W mice. Journal of Rheumatology. Supplement 14(Suppl. 13): 158-165, 1987