+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Induction of ovulation in idiopathic premature ovarian failure: a randomized double-blind trial



Induction of ovulation in idiopathic premature ovarian failure: a randomized double-blind trial



Reproductive Biomedicine Online 15(2): 215-219



In this prospective randomized study, women with idiopathic karyotypically normal premature ovarian failure (POF) were treated with gonadotrophin-releasing hormone (GnRH) agonist and gonadotrophins with and without the addition of corticosteroids in an attempt to restore ovarian function. The study comprised 58 women with idiopathic POF randomly allocated to either GnRH agonists (GnRHa) plus gonadotrophin therapy with the addition of corticosteroids (29 patients) or GnRHa plus gonadotrophin therapy with placebo (29 patients). Ovulation occurred in six cases (20.7%) in the dexamethasone group versus three cases (10.3%) in the placebo group. There were two singleton pregnancies in the dexamethasone group. There were no reported complications from the use of dexamethasone apart from a sense of sleepiness and fatigue. The combination of corticosteroids with pituitary suppression followed by ovarian stimulation with gonadotrophin appeared to be beneficial in restoring ovarian function in patients with idiopathic POF and normal karyotype.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053822562

Download citation: RISBibTeXText

PMID: 17697500

DOI: 10.1016/s1472-6483(10)60711-0


Related references

Ovulation induction in premature ovarian failure: a placebo-controlled randomized trial combining pituitary suppression with gonadotropin stimulation. Fertility and Sterility 64(2): 273-278, 1995

Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 90(7): 4068-4074, 2005

Induction of labor with oral misoprostol for premature rupture of membranes at term in women with unfavorable cervix: a randomized, double-blind, placebo-controlled trial. Journal of Perinatal Medicine 35(2): 126-129, 2007

Premature ovarian failure: predictability of intermittent ovarian function and response to ovulation induction agents. Current Opinion in Obstetrics & Gynecology 20(4): 416-420, 2008

Ovulation induction by glucocorticoids in premature ovarian failure. Clinical & Investigative Medicine 15(4 SUPPL): A36, 1992

Adjuvant growth hormone for induction of ovulation with gonadotrophin-releasing hormone agonist and gonadotrophins in polycystic ovary syndrome: a randomized, double-blind, placebo controlled trial. Human Reproduction 10(10): 2550-2553, 1995

Ovulation induction in a woman with premature ovarian failure using buserelin and metrodin. Journal of Obstetrics & Gynaecology (Abingdon) 11(2): 153, 1991

Premature ovarian failure--the prognostic application of autoimmunity on conception after ovulation induction. Fertility and Sterility 59(4): 750-755, 1993

The effect of gonadotropin suppression on the induction of ovulation in premature ovarian failure patients. Fertility and Sterility 52(1): 36-41, 1989

Ovulation induction in women with premature ovarian failure: a prospective, crossover study. Fertility and Sterility 57(2): 448-449, 1992

Increased exercise ejection fraction and reversed remodeling after long-term treatment with metoprolol in congestive heart failure: a randomized, stratified, double-blind, placebo-controlled trial in mild to moderate heart failure due to ischemic or idiopathic dilated cardiomyopathy. European Journal of Heart Failure 5(5): 679-691, 2003

Ovulation induction in premature ovarian failure pof patients after estrogen induced gonadotropin suppression. The American Fertility Society Scientific Papers to Be Presented at The 43rd Annual Meeting Of The American Fertility Society, Reno, Nevada, Usa, September 28-30, Xxii+134p The American Fertility Society: Birmingham, Alabama, Usa Paper : 3, 1987

Ovulation induction with clomiphene citrate in a women with premature ovarian failure. A case report. Journal of Reproductive Medicine 33(6): 559-562, 1988