EurekaMag.com logo
+ Site Statistics
References:
54,215,046
Abstracts:
30,230,908
PMIDs:
28,215,208
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Industrial methodology for process verification in research (IMPROVER): toward systems biology verification



Industrial methodology for process verification in research (IMPROVER): toward systems biology verification



Bioinformatics 28(9): 1193-1201



Analyses and algorithmic predictions based on high-throughput data are essential for the success of systems biology in academic and industrial settings. Organizations, such as companies and academic consortia, conduct large multi-year scientific studies that entail the collection and analysis of thousands of individual experiments, often over many physical sites and with internal and outsourced components. To extract maximum value, the interested parties need to verify the accuracy and reproducibility of data and methods before the initiation of such large multi-year studies. However, systematic and well-established verification procedures do not exist for automated collection and analysis workflows in systems biology which could lead to inaccurate conclusions. We present here, a review of the current state of systems biology verification and a detailed methodology to address its shortcomings. This methodology named 'Industrial Methodology for Process Verification in Research' or IMPROVER, consists on evaluating a research program by dividing a workflow into smaller building blocks that are individually verified. The verification of each building block can be done internally by members of the research program or externally by 'crowd-sourcing' to an interested community. www.sbvimprover.com This methodology could become the preferred choice to verify systems biology research workflows that are becoming increasingly complex and sophisticated in industrial and academic settings.

(PDF emailed within 0-6 h: $19.90)

Accession: 053823877

Download citation: RISBibTeXText

PMID: 22423044

DOI: 10.1093/bioinformatics/bts116



Related references

A data integration methodology for systems biology: experimental verification. Proceedings of the National Academy of Sciences of the United States of America 102(48): 17302-7, 2005

Research on metrological verification and the development of the verification equipment for digital electrocardiographs. Zhongguo Yi Liao Qi Xie Za Zhi 29(5): 349-351, 2006

Regulatory verification of industrial HACCP systems. Food Technology Chicago 45(4): 144-146, 1991

Automatic verification of safety interlock systems for industrial processes. Journal of Loss Prevention in the Process Industries 14(5): 379-386, 2001

Practical guidelines for routine intensity-modulated radiotherapy verification: pre-treatment verification with portal dosimetry and treatment verification with in vivo dosimetry. British Journal of Radiology 83(995): 949-957, 2010

A research and the experimental verification of various systems of goose fattening. Pol'nohospodarstvo = Sel'skoe khoziaistvo = Agriculture: 126-1134, 1981

Research into, and experimental verification of, various systems of goose fattening. Pol' nohospodarstvo 27(12): 1124-1134, 1981

Is verification possible? The evaluation of large econometric models. In: Proceeding papers, Winter meeting of the American Agricultural Economics Association with Allied Social Science Associations, Toronto December 28-30, 1972. The validity and verification of complex systems models. American Journal of Agricultural Economics 55(2): 250-258, 1973

Harmonization of IEEE 1012 and IEC 60880 standards regarding verification and validation of nuclear power plant safety systems software using model-based methodology. Progress in Nuclear Energy 99: 86-95, 2017

The 1999 Cotton Research Verification Program (CRVP): comparison of irrigation systems. Special Report Arkansas Agricultural Experiment Station ( 198): 271-274, 2000

Can self-verification strivings fully transcend the self-other barrier? Seeking verification of ingroup identities. Journal of Personality and Social Psychology 97(6): 1021-1044, 2010

Verification of marine forecasts using an objective area forecast verification system. Meteorological Applications 20(2): 224-235, 2013

Assessment of technician barcode scanning verification compared to pharmacist verification. American Journal of Health-System Pharmacy 76(3): 148-152, 2019

Result verification, code verification and computation of support values in phylogenetics. Briefings in Bioinformatics 12(3): 270-279, 2011

MLC positioning verification for small fields: a new investigation into automatic EPID-based verification methods. Australasian Physical & Engineering Sciences in Medicine: -, 2018