+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Influence of estrogen levels on thermal perception, pain thresholds, and pain tolerance: studies on women undergoing in vitro fertilization

Influence of estrogen levels on thermal perception, pain thresholds, and pain tolerance: studies on women undergoing in vitro fertilization

Journal of Pain 13(5): 459-466

We examined the relationship between estrogen and pain in women undergoing in vitro fertilization (IVF). Quantitative sensory tests (QST) were performed twice during the IVF-regimen: once during hormonal down-regulation and once during hormonal up-regulation. A group of healthy men and a group of women using monophasic contraceptives were also examined, to control for session-to-session effects. Among the women undergoing IVF, serum 17?-estradiol levels differed strongly between treatments as expected, and increased from 65.7 (SD = 26) pmol/L during the down-regulation phase, to 5,188 (SD = 2,524) pmol/L during the up-regulation phase. Significant outcomes in the QST were only seen for temperature perception thresholds (1.7 C versus 2.2 C; P = .3) and cold pain threshold (11.5 C versus 14.5 C; P = .4). A similar change in cold pain threshold was also seen in the 2 control groups, however, and statistical analysis suggested that this change was due to a session-to-session effect rather than being the result of hormonal modulation. Heat pain thresholds, heat tolerance, pressure pain thresholds, and the cold pressor test showed no significant differences between sessions. These data demonstrate that pain perception and pain thresholds in healthy women show little, if any, changes even with major variations in serum estradiol levels. Perspective This study shows that pain perception and tolerance in women undergoing in vitro fertilization do not vary, despite the dramatic changes in 17?-estradiol levels induced by the treatment regimen. The result thus suggests that in humans, contrary to experimental animals, changes in estrogen levels have little influence on pain sensitivity.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 053842091

Download citation: RISBibTeXText

PMID: 22480441

DOI: 10.1016/j.jpain.2012.01.446

Related references

Thermal detection and pain thresholds but not pressure pain thresholds are correlated with psychological factors in women with chronic whiplash-associated pain. Clinical Journal of Pain 28(3): 211-221, 2012

Do ethnicity and gender have an impact on pain thresholds in minor dermatologic procedures? A study on thermal pain perception thresholds in Asian ethinic groups. Skin Research and Technology 10(1): 38-42, 2004

Psychophysically determined thresholds for thermal perception and pain perception in healthy women across the menstrual cycle. Clinical Journal of Pain 22(7): 610-616, 2006

Reproducibility and influence of test modality order on thermal perception and thermal pain thresholds in quantitative sensory testing. Clinical Neurophysiology 121(11): 1878-1885, 2010

Pain-related anxiety influences pain perception differently in men and women: a quantitative sensory test across thermal pain modalities. Pain 154(3): 419-426, 2013

Thresholds and perception of cold pain, heat pain, and the thermal grill illusion in patients with major depressive disorder. Psychosomatic Medicine 75(3): 281-287, 2013

Chronic pain has a small influence and mood has no influence on vibrotactile perception thresholds among working women. Muscle and Nerve 42(3): 401-409, 2010

Comparison of pain thresholds and pain tolerance levels between Middle Easterners and Swedes and between genders. Journal of Oral Rehabilitation 36(4): 271-278, 2009

Relationships between widespread pain and thresholds pain tolerance on tender points in Portuguese women with fibromyalgia: impact on daily life. Acta Reumatologica Portuguesa 40(3): 254-261, 2017

Preoperative pain training. No influence on postoperative pain perception in patients undergoing cardiac surgery. Schmerz 20(4): 315, 2006

Influence of age on thermal thresholds, thermal pain thresholds, and reaction time. Journal of Clinical Neuroscience 17(6): 722-726, 2010

Influence of physical activity levels on pain perception in college women. Medicine & Science in Sports & Exercise 35(5 Suppl.): S27, 2003

Perception thresholds for cold warmth and thermal pain in a normal populations. Pain (Suppl. 4): S313, 1987

Effects of nondirective suggestions on pain tolerance, pain threshold and pain intensity perception. Perceptual and Motor Skills 84(3 Pt 1): 963-966, 1997