+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Influence of obstructive sleep apnea on left ventricular mass and global function: sleep apnea and myocardial performance index



Influence of obstructive sleep apnea on left ventricular mass and global function: sleep apnea and myocardial performance index



Heart and Vessels 25(5): 400-404



Obstructive sleep apnea (OSA) is associated with cardiovascular mortality and morbidity. It may predispose patients to left ventricular hypertrophy and heart failure. The aim of this study was to determine the left ventricular mass (LVM) and myocardial performance index (MPI) reflecting left ventricular global function in uncomplicated OSA patients. Sixty-four subjects without hypertension, diabetes mellitus, and any cardiac or pulmonary disease referred for evaluation of OSA underwent overnight polysomnography and complete echocardiographic assessment. According to the apnea hypopnea index (AHI), subjects were divided into three groups: group 1, control subjects with nonapneic snorers (AHI < 5, n = 18); group 2, patients with mild to moderate OSA (AHI: 5-30, n = 25); and group 3, severe OSA (AHI > 30, n = 21). Basic echocardiographic measurements, LVM, and LVM index were measured. Left ventricular MPI was calculated as (isovolumic contraction time+isovolumic relaxation time)/aortic ejection time by Doppler echocardiography. There were no significant differences in age, sex, body mass index, heart rate, and systolic and diastolic blood pressure among the three groups. Left atrium, interventricular septum, left ventricular posterior wall, left ventricular end-diastolic and end-systolic diameters, LVM mass, and LVM index were not significantly different among the three groups. Left ventricular MPI was significantly higher in severe OSA patients (0.64 +/- 0.18) than in controls (0.49 +/- 0.18; P < 0.05). There was no significant difference between controls (0.49 +/- 0.18) and mild to moderate OSA (0.61 +/- 0.16; P = 0.08) and between mild to moderate OSA (0.61 +/- 0.16) and severe OSA (0.64 +/- 0.18; P = 0.84). The present study demonstrates that patients with severe OSA have global left ventricular dysfunction.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 053846569

Download citation: RISBibTeXText

PMID: 20676962

DOI: 10.1007/s00380-009-1225-3


Related references

Impact of obstructive sleep apnea on right ventricular global function: sleep apnea and myocardial performance index. Respiration; International Review of Thoracic Diseases 72(3): 278-284, 2005

Serum levels of adipocyte fatty acid-binding protein are independently associated with left ventricular mass and myocardial performance index in obstructive sleep apnea syndrome. Journal of Investigative Medicine 60(7): 1020-1026, 2013

The study on relations between left ventricular function, body mass index and respiratory function on the patients with obstructive sleep apnea syndrome. Journal of China Medical University 31(1): 38-39, 2002

Effect of nasal continuous positive airway pressure in men on global left ventricular myocardial performance in patients with obstructive sleep apnea syndrome. American Journal of Cardiology 101(12): 1796-1800, 2008

Decreased Right and Left Ventricular Myocardial Performance in Obstructive Sleep Apnea. Yearbook of Pulmonary Disease 2009: 280-281, 2009

Decreased right and left ventricular myocardial performance in obstructive sleep apnea. Chest 132(6): 1863-1870, 2007

Obstructive sleep apnea in epilepsy patients: the Sleep Apnea scale of the Sleep Disorders Questionnaire (SA-SDQ) is a useful screening instrument for obstructive sleep apnea in a disease-specific population. Sleep Medicine 4(6): 517-521, 2003

Effects of untreated obstructive sleep apnea on left and right ventricular myocardial function. International Journal of Cardiology 155(3): 465-469, 2012

Relationship between obstructive sleep apnea severity index and left ventricular function and volume. Annals of Saudi Medicine 32(4): 384-390, 2012

Impact of obstructive sleep apnea on left ventricular mass and diastolic function. American Journal of Respiratory and Critical Care Medicine 163(7): 1632-1636, 2001

Left Ventricular Mass Index and Pulmonary Artery Pressure in Patients with the Obstructive Sleep Apnea Syndrome. Journal of Tehran Heart Center 11(1): 11-14, 2016

Effects of CPAP on right ventricular myocardial performance index in obstructive sleep apnea patients without hypertension. Respiratory Research 7: 22, 2006

Integrated area of desaturation, a new index of sleep-disordered breathing, is associated with left ventricular hypertrophy among hypertensive men with obstructive sleep apnea. European Heart Journal 34(Suppl 1): P2372-P2372, 2013

Depressive symptoms are associated with poor sleep quality rather than apnea-hypopnea index or hypoxia during sleep in patients with obstructive sleep apnea. Sleep and Breathing 21(4): 997-1003, 2017

Impact of untreated obstructive sleep apnea on left and right ventricular myocardial function and effects of CPAP therapy. Plos One 8(10): E76352, 2014